Urophenasin 10 mg (solifenacin succinate)

Adult dose

The usual recommended dose for adults (including the elderly) is 5 mg once daily. If necessary, the dose may be increased to a maximum of 10 mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dosage adjustment is necessary in the following patients. 1. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30 ml/min). Caution is required in patients with severe renal impairment (creatinine clearance≤30 ml/min), and the dose should not exceed 5 mg once daily. 2. Patients with hepatic impairment No dosage adjustment is necessary in patients with mild hepatic impairment. Caution is required in patients with moderate hepatic impairment (Child-Pugh class B), and the dose should not exceed 5 mg once daily. 3. Patients receiving strong cytochrome P450 3A4 (CYP3A4) inhibitors For patients receiving ketoconazole or another strong CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5 mg.

This medicine should not be used in patients with certain diseases. For example, patients with urinary retention who have difficulty urinating, those with serious gastrointestinal disorders, patients with myasthenia gravis, and those with glaucoma should not take this medication. Moreover, individuals allergic to this drug or its ingredients, patients undergoing hemodialysis, and those with severe liver or kidney dysfunction should not use this medication. This drug should be used cautiously in patients at risk of urinary retention due to bladder outlet obstruction, those with gastrointestinal obstruction diseases, or patients with impaired gastrointestinal motility. Especially, patients with moderate to severe impaired kidney or liver function should use a reduced dose, and caution is also required when taken with certain potent medications. The most common side effects of this medication include dry mouth and constipation. Additionally, blurred vision or dry eyes may occur, and in some patients, symptoms of urinary retention may be observed. In severe cases, serious side effects such as intestinal obstruction, angioedema, or allergic reactions can occur, so if any abnormal symptoms appear, immediate consultation with a healthcare professional is necessary. This medication may require caution when driving or operating machinery, as drowsiness, fatigue, or blurred vision may occur. Taking this drug with other anticholinergic medications may enhance effectiveness or increase side effects. Additionally, as this medicine is metabolized by certain liver enzymes, dosage adjustment is necessary when taken with drugs affecting liver metabolism. During pregnancy, the safety of this medication has not been sufficiently established, so caution is advised, and nursing women should avoid using this medication. It should not be used in children as safety and efficacy have not been established. In case of overdose, symptoms such as headache, dizziness, drowsiness, and blurred vision may occur, and in such cases, immediate medical treatment should be sought. Finally, this drug may pose risks for cardiac-related side effects in patients with heart disease or specific cardiac rhythm abnormalities, so caution is warranted.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colon obstruction
• intestinal obstruction
• vasogenic edema
• nausea

This medication should be stored in a sealed container to prevent exposure to air or moisture, and it is best to keep it at room temperature between 1°C and 30°C. Storing it in this manner will help maintain the drug's effectiveness for a longer period.

Appearance

Bright pink round film-coated tablets

Package unit

100 tablets (10 tablets/PTP x 10)