Oklan Tablet (Amoxicillin and Clavulanate Potassium)

Adult dose

Adults and children aged 12 years and older or weighing over 40 kg are to take 250 mg/125 mg of Amoxicillin/Clavulanate potassium orally three times a day every 8 hours. In cases of severe and respiratory infections, the dosage may be increased to 500 mg/125 mg. In cases of renal impairment, the dosage should be adjusted based on creatinine clearance. For creatinine clearance of 10 to 30 mL/min, administer 250 mg of Amoxicillin every 12 hours.

Child dose

Adults and children aged 12 years and older or weighing over 40 kg are dosed the same way. For children with renal impairment, the dosage is adjusted based on creatinine clearance.

This medication is a beta-lactam antibiotic and should not be used in patients with a history of certain allergies. For instance, patients who have had hypersensitivity reactions to this medication's ingredients or penicillin drugs may experience severe allergic reactions if they take this medication. Additionally, patients with infectious mononucleosis or lymphocytic leukemia are at higher risk of developing rashes when taking this medication, so caution is advised. Patients with liver function issues should also use this medication cautiously as it may worsen liver function. For patients with impaired liver function or moderate to severe renal impairment, the concentration of this medication can remain in the body for prolonged periods, necessitating adjustments in dosing intervals. Patients with allergies or gastrointestinal symptoms such as vomiting and diarrhea should consult a doctor before taking this medication. This medication can cause various gastrointestinal side effects, including diarrhea, nausea, and abdominal pain; to minimize gastrointestinal discomfort, it is advisable to take it with food. Symptoms of liver dysfunction may also occur, especially in the elderly or with long-term use, thus regular liver function tests are needed. Rarely, severe skin rashes or allergic reactions may occur; if any unusual skin symptoms arise, discontinue use immediately and inform healthcare providers. Blood abnormalities may also occur, so any signs of bleeding tendency or anemia should be discussed with a doctor. Central nervous system side effects may include dizziness, drowsiness, and rarely seizures, so caution is warranted. Patients with impaired renal function may experience worsening kidney damage when taking this medication, hence regular monitoring is crucial. This medication can interact with other drugs, so any current medications should be disclosed. Pregnant or breastfeeding women should use this medication cautiously after consulting a doctor, as it may affect the fetus or infant. This medication is not recommended for children under 12 years of age or those weighing less than 40 kg. The elderly have a higher risk of side effects due to reduced bodily function, so dosage and dosing intervals should be adjusted and closely monitored. Regular blood tests for liver function, kidney function, and blood counts during treatment with this medication are important to check for anomalies. In cases of overdose, symptoms may include vomiting, diarrhea, and seizures requiring immediate medical attention.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by coughing and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, liver abnormalities (jaundice), sudden and intense

Mild side effects

Diarrhea, pseudomembranous colitis, indigestion, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, loss of appetite, abdominal pain, abdominal distension, constipation, colonic pain, hyperacidity, loose stools, dry mouth, acute pancreatitis, candidiasis, colitis, hepatitis, elevated AST, ALT, ALP, LDH, serum bilirubin, itching, polymorphic eruption, mucous membrane syndrome, toxic epidermal necrolysis, vesicular exfoliative dermatitis, acute generalized exanthematous pustulosis, angioedema,

This medication should be kept in a tightly sealed container to prevent moisture and stored in a cool, dry place between 1°C and 25°C. Storing it this way helps maintain the effectiveness of the medication for a longer period.

Appearance

White or almost white oval film-coated tablets

Package unit

30 tablets/PTP (6 tablets/TPP x 5)