Osclo Tablets (Clarithromycin)

Adult dosage

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be coadministered with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years or older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This medication should not be used in certain patients. Patients with allergies to any component of this medication or who have had hypersensitivity reactions to similar classes of antibiotics should not take it. Additionally, patients taking certain medications may experience heart problems when taking this medication, so they should avoid its use. Caution is required in patients with significant heart conditions or with severely impaired liver or kidney function, and it should not be given to pregnant or breastfeeding women. This medication may lead to various side effects, so if any unusual symptoms appear while using it, it should be discontinued immediately and a doctor consulted. Notably, allergic reactions, gastrointestinal problems, abnormal liver or kidney functions, central nervous system symptoms, and skin adverse reactions have been reported. This medication interacts with many other drugs, so it is essential to inform the doctor or pharmacist of any other medications being taken, especially heart-related medications, drugs affecting liver metabolism, blood glucose-lowering agents, and anticoagulants. It is safest for pregnant or breastfeeding women not to take this medication, and if unavoidable, they should consult a professional. Caution is necessary for children and the elderly as their bodily functions may differ, thus requiring dose adjustments or careful monitoring. Overdose may result in gastrointestinal disorders or central nervous system abnormalities, requiring immediate medical attention. This medication can lead to resistant bacteria with prolonged or repeated use, so the prescribed duration and dosage must be adhered to precisely. Additionally, caution should be exercised while driving or operating machinery as dizziness or confusion may occur. Regular blood tests and liver and kidney function tests are recommended to monitor for abnormalities.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, pruritus, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal ulceration, epigastric pain, convulsive type, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, taste disorder, appetite loss, constipation, discoloration of stool, membranous colitis, hemorrhagic colitis, bloody stools, fever, cough, dyspnea, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, appetite loss, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, increased CPK, elevated serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, elevated AST, elevated ALT, elevated BUN, thrombocytopenia, leukopenia, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, dry mouth, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, pruritus, urticaria, papular rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash, acne, Henoch-Schonlein purpura, acute generalized pustular psoriasis, muscle spasms, musculoskeletal stiffness, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, increased blood urea, renal failure, nephritis, venous thrombophlebitis at injection site, injection site pain, inflammation at injection site, fatigue, fever, asthenia, chest pain, chills, fatigue, abnormal albumin/globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental status, obsessive behavior, hypokalemia, hypoxemia

This medication should be stored in a container that blocks light as it is sensitive to light. Additionally, it should be stored at room temperature between 15 to 30 degrees Celsius to maintain its effectiveness.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets per bottle, 200 tablets per bottle