Famciclovir Tablets (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: The usual dose of famciclovir is 250 mg per dose, taken orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes Adults: The usual dose of this medicine is 250 mg per dose, taken orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of an acute recurrent episode of genital herpes Adults: The usual dose of this medicine is 125 mg per dose, taken orally 2 times daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: The usual dose of this medicine is 250 mg per dose, taken orally 2 times daily. Discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because creatinine clearance of this medicine is reduced in patients with renal impairment, dosage adjustment should be made with caution. The dosage for these patients is as follows. 1) Treatment of herpes zoster and an initial episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose, 2 times daily 10～29 250 mg per dose, once daily 2) Treatment of an acute recurrent episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59 125 mg per dose, 2 times daily 10～29 125 mg per dose, once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose, 2 times daily 10～29 125 mg per dose, 2 times daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with evident chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used in patients who have had allergic reactions to this medication or its components. This medication contains lactose, therefore it should not be administered to patients with genetic disorders that impair lactose digestion. Patients with impaired kidney function should use this medication with caution and the dosage may be adjusted according to the physician's instructions. Mild side effects such as headache or nausea may occur during treatment, but these are generally not severe. Rarely, decreased blood cell counts, mental confusion, drowsiness, or hallucinations may occur, so consult a doctor immediately if any unusual symptoms occur. This medication does not completely cure genital herpes, so it is important to avoid sexual intercourse while symptoms are present and to maintain safe sexual practices. If dizziness or drowsiness occurs while taking this medication, avoid driving or operating machinery. Patients with slightly impaired liver function do not require special dosage adjustments, but those with severe liver impairment may experience reduced effectiveness of this medication. There may be potential interactions when used with other medications, so patients should inform their doctor or pharmacist of any medications they are currently taking. Women who are pregnant or breastfeeding should discuss the necessity of using this medication with their physician before taking it. Use in children under 18 years of age is not recommended as safety and efficacy have not been established. In elderly patients, dosage adjustments may be necessary according to kidney function, so follow the physician's instructions. In case of overdose, visit a medical institution immediately for appropriate treatment, and blood dialysis can reduce the concentration of this medication in the body. This medication should be stored in a tightly sealed container, protected from air and moisture. It should also be kept in a cool and dry place, below 30 degrees Celsius, to maintain its effectiveness. Transferring to other containers may cause a decline in quality or accidents, so care should be taken.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication should be stored in a sealed container to prevent exposure to air or moisture. Additionally, it should be placed in a cool, dry place below 30 degrees Celsius to maintain its effectiveness.

Appearance

White, round, film-coated tablets

Package unit

21 tablets/bottle