Hipresil Tablet 23mg (Donepezil Hydrochloride Monohydrate)

Adult dose

This medicine is taken once daily in the evening, immediately before bedtime, and may be administered regardless of food. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, consider taking this medicine in the morning. This medicine should not be divided, crushed, or chewed, as this may increase the rate of absorption. The initial recommended dose of donepezil hydrochloride is 5mg once daily. This medicine reaches steady state 15 days after administration, and the incidence of adverse reactions may be affected by the rate of dose escalation; therefore, administer 5mg for 4 ~ 6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10mg. When increasing the dose to 10mg daily, administer with caution for gastrointestinal adverse reactions. Patients who have taken 10mg once daily for at least 3 months may be given 23mg once daily.

This medication should not be used in patients allergic to certain ingredients or in women who are pregnant or breastfeeding. Patients with genetic issues such as lactose intolerance should also avoid this medication. Patients with heart disease or conduction disorders should be cautious as this medication may cause slowed heart rate or arrhythmia. Those taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this medication cautiously as there may be a risk of gastrointestinal bleeding or exacerbation of ulcers. Patients with a history of asthma or obstructive pulmonary disease should be careful as respiratory symptoms may worsen. Patients with extrapyramidal disorders such as Parkinson's disease should take this medication under professional supervision due to the risk of exacerbation of symptoms. This medication can cause a variety of side effects; in severe cases, symptoms such as fainting, heart issues, gastrointestinal bleeding, liver dysfunction, cerebral hemorrhage, seizures, and muscle-related disorders may occur. Mild side effects may commonly include nausea, vomiting, diarrhea, dizziness, insomnia, headache, and fatigue. Patients with heart disease may have an increased risk of arrhythmia and may require an ECG. Additionally, this medication may interact with other drugs, so anyone taking other medications should consult with a doctor or pharmacist. Pregnant or breastfeeding women should avoid this medication unless absolutely necessary and should discuss with a specialist before proceeding. This medication has not established safety in children and should not be used in this population. In case of overdose, symptoms may include vomiting, sweating, bradycardia, respiratory depression, and immediate medical treatment is required. This medication should be stored in a sealed container to prevent air entry and kept out of reach of children; it is best not to transfer it to another container.

Syncope, bradycardia, heart block, prolonged QT interval, myocardial infarction, heart failure, peptic ulcer, perforated duodenal ulcer, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizure, epilepsy, convulsions, cerebral hemorrhage, cerebrovascular disorder, movement dysfunction, ataxia, movement disorder, dystonia, tremor, involuntary movements, gait disturbance, abnormal posture, speech impairment, akinetic mutism, extreme muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, rhabdomyolysis, myalgia, weakness, dyspnea, acute pancreatitis, acute renal failure, sudden death, cold, loss of appetite, hallucination, agitation, aggressive behavior, anxiety disorder, insomnia, drowsiness, increased libido, talkativeness, mania, nightmare, nervousness, nonsense, delusion, depression, confusion, apathy, hyperactivity, increased libido, hypersexuality, dizziness, tremor, seizure, stupor, chest wall rigidity, bradycardia, palpitations, sinoatrial block, atrioventricular block, hypertension, hypotension, atrial fibrillation, torsades de pointes, QT interval prolongation on electrocardiogram, diarrhea, nausea, vomiting, abdominal disorders, gastrointestinal bleeding, gastric and duodenal ulcer, constipation, salivation, fecal incontinence, hepatitis, rash, itching, muscle cramps, myalgia, urinary incontinence, polyuria, urinary retention, headache, fatigue, pain, toothache, facial flushing, malaise, lethargy, edema, fever, decreased body temperature, decreased hematocrit, leukopenia, anemia, thrombocytopenia, petechiae, abnormal dreams, vomiting, decreased appetite, urinary tract infection, dehydration, hyperlipidemia, insomnia, hostility, irritability, drowsiness, depression, confusion, emotional instability, personality disorder, eczema, urinary incontinence, contusion, abdominal pain, weakness, fungal infection, influenza-like illness, allergy, soft tissue infection, malaise, sepsis, facial edema, hernia, hypotension, ECG abnormalities, heart failure, constipation, gastroenteritis, fecal incontinence, dyspepsia, increased γ-GT, gastritis, dysphagia, periodontitis, gastric ulcer, periodontal abscess, abdominal distension, abnormal liver function, belching, esophagitis, anal bleeding, diabetes, anemia, leukocytosis, weight loss, peripheral edema, edema, increased LDH, increased alkaline phosphatase, hypercholesterolemia, hypokalemia, hypoglycemia, weight gain, hyperbilirubinemia, increased BUN, vitamin B12 deficiency anemia, cachexia, increased creatinine, gout, hyponatremia, hypoproteinemia, iron deficiency anemia, increased AST, increased ALT, arthritis, arthrosis, bone fracture, arthralgia, leg cramps, osteoporosis, myalgia, restlessness, anxiety, convulsions, polymorphic psychiatric disturbances, gait disorder, apathy, delusion, dream abnormalities, cerebrovascular abnormalities, increased salivation, ataxia, euphoric state, vasodilation, cerebral hemorrhage, cerebral infarction, cerebral ischemia, dementia, extrapyramidal symptoms, generalized tonic-clonic seizures, hemiplegia, hypertonia, hypokinesia, pharyngitis, pneumonia, increased cough, bronchitis, dyspnea, rhinitis, asthma, rash, skin ulcer, itching, psoriasis, skin discoloration, herpes zoster, dry skin, sweating, urticaria, vesicular rash, conjunctivitis, glaucoma, visual disturbances, ear pain, tear abnormalities, urinary tract infection, cystitis, hematuria, diabetes, vaginitis, dysuria, polyuria, proteinuria, abdominal pain, restlessness, cholecystitis, confusion, convulsions, hallucination, heart block, hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, rash, excessive salivation, sweating, hypotension, respiratory depression, weakness, convulsions, muscle weakness symptoms

This medication should be stored in a sealed container to prevent air entry, and it is best kept at room temperature between 1°C and 30°C. Storing it this way helps maintain the effectiveness of the medication.

Appearance

Brownish-red round film-coated tablet

Package unit

30 tablets per bottle