GCNAC Injection (Acetylcysteine)

Adult administration

1. Mucolysis 1) Intravenous injection: For acetylcysteine, 600 to 900 mg is injected 2 to 3 times a day. The injection should be diluted with saline injection or 5% dextrose injection and infused slowly (over about 5 minutes). 2) Intramuscular injection: 300 mg is injected 1 to 2 times a day. 3) Antidote for acetaminophen overdose: 150 mg is administered per kg body weight in 5% dextrose solution 200 mL within the first 15 minutes.

Child administration

1. Mucolysis 1) Intravenous injection: For this medication, 300 to 450 mg is injected 2 to 3 times a day.

This medication is a glass ampule injection, so care must be taken to avoid mixing glass fragments when opening the container. Extra caution is advised when administering to children and the elderly. It should not be used in individuals with allergies to this medication or its components. Caution is also warranted in patients with bronchial asthma or impaired respiratory function, and treatment should be stopped immediately if adverse effects occur. It is advisable not to use it in newborns unless they have severe illnesses. During use, gastrointestinal symptoms such as nausea, vomiting, anorexia, and diarrhea may occur. Additionally, hypersensitivity reactions like urticaria, itching, rash, headache, tinnitus, and bronchospasm may occur rarely. Tachycardia or hypertension may also appear rarely, and very rarely severe allergic reactions such as anaphylaxis can occur. When used as an antidote, infusion of large doses may lead to symptoms similar to hypersensitivity reactions, prompting immediate discontinuation if symptoms arise. During use, mucus secretions may increase, so patient condition should be closely monitored, and appropriate measures such as mechanical suction or position changes should be taken if necessary. When administered via intramuscular injection, deep injection is required. For use as an antidote, it is best to administer within 10 hours of overdose. Caution is necessary when using this medication in conjunction with certain other drugs due to potential physicochemical reactions. Safety during pregnancy has not been established, so it should only be used if absolutely necessary. Breastfeeding women should use it cautiously, as it may be excreted in breast milk. Elderly patients should be observed closely and administered carefully due to possible reduced physical function.

Serious side effects

• Urticaria
• bronchospasm
• anaphylaxis
• respiratory distress
• angioedema

Mild side effects

• Nausea
• vomiting
• anorexia
• diarrhea
• itching
• rash
• headache
• tinnitus
• tachycardia
• hypertension

This medication should be stored in a sealed container that shields it from light, and it is safely stored at room temperature between 1 and 30 degrees Celsius. This storage method helps maintain the effectiveness of the drug and prevents degradation.

Appearance

Brown ampoule injection containing a colorless and transparent liquid

Package unit

3mL × 10 ampoules