MPDIL Tablet (Methylprednisolone)

Adult dosage

The initial dose may vary from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, although a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is achieved. If satisfactory clinical results are not obtained after a reasonable period, discontinue treatment and switch to another appropriate therapy. The dose must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, determine the appropriate maintenance dose by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. Continuous monitoring of the dose is required. Situations that may require dose adjustment include improvement or worsening of the disease, individual patient responsiveness to the medication, and the effects on the patient of exposure to stressful circumstances that have no direct impact on the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dose for a period sufficient to adequately manage the patient's condition. After long-term treatment, gradual dose reduction is recommended when discontinuing the medication. For the treatment of acute exacerbations of multiple sclerosis, administration of prednisolone 200mg daily for 1 week followed by prednisolone 80mg every other day for 1 month is effective (4mg of methylprednisolone is equivalent to 5mg of prednisolone). Alternate-day therapy is a regimen in which twice the daily dose is administered on one morning every other day. The initial suppressive dose should be continued until a satisfactory clinical response is obtained, usually for 4 to 10 days in many allergic and collagen diseases. ① Switch to ADT and gradually reduce the amount of corticosteroid given every other day. ② Reduce the daily dose of corticosteroid to the minimum effective dose as soon as possible, according to control of disease progression, and then switch to an alternate-day schedule. If this proves difficult, it is preferable to administer 3 or even 4 times the daily dose every other day rather than simply doubling the daily dose. Once the patient's condition is controlled again, attempt to reduce this dose to the minimum. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in 4 divided doses every 6 hours, there is evidence that when pharmacologic doses are used, a slight suppressive effect on adrenal activity continues into the following day.

This medication should not be used in certain patients. For example, it should not be administered to patients allergic to this medication or its components, patients with incurable infections, or patients with herpes simplex, herpes zoster, or chickenpox. Additionally, this medication should not be used in patients receiving live vaccines or those with certain genetic issues, such as lactose intolerance. In some patients, it should be used with caution, especially if they have glaucoma, tuberculosis, peptic ulcers, hypertension, thrombosis, psychiatric disorders, osteoporosis, diabetes, or cardiovascular disease; it should only be administered cautiously when absolutely necessary. This medication can cause various side effects, so if any symptoms such as edema, increased blood pressure, muscle weakness, dyspepsia, skin changes, changes in mental state, endocrine abnormalities, eye diseases, or immune system issues occur, immediate consultation with a healthcare provider is essential. Long-term use can lead to adrenal insufficiency, and abrupt discontinuation can be dangerous; therefore, the dosage should be gradually reduced. In stressful situations such as infections or surgeries, an increase in dosage may be necessary. During treatment with this medication, there is a higher vulnerability to infections, so care should be taken to avoid exposure to chickenpox or measles, and vaccinations should be limited. Moreover, it could interact with various medications, so if taking other drugs, it is critical to inform your doctor or pharmacist. Pregnant or nursing individuals should use this medication only when absolutely necessary, as it may affect the fetus or newborn; it is safest to discontinue breastfeeding. In children, it may impact growth, so only the minimum dose should be administered, and careful monitoring is required. Elderly patients are at higher risk for side effects, thus requiring more cautious administration. When using this medication, it is important to fully understand the above considerations, as regular check-ups and vigilant monitoring are necessary.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, avascular necrosis of the femoral and humeral epiphyses, steroid myopathy, loss of muscle mass, pathologic fractures of the iliac bone, osteoporosis, spinal compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, dry mouth, vomiting, stomach pain, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, ulcerative esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechial hemorrhage, purpura, suppression of skin reactions, purpura, acne, hirsutism, hair loss, pigmentation, papilledema, increased intracranial pressure, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual disorders, pediatric growth suppression, symptoms of latent diabetes, secondary adrenal insufficiency, pituitary unresponsiveness, impaired glucose tolerance, increased demand for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior subcapsular cataract, secondary eye infections, central serous chorioretinopathy, retinal disorders, exophthalmos, catabolism, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication may be sensitive to air and moisture, so it must be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius. This will help sustain the effectiveness of the medication for a longer period.

Appearance

White round tablets

Package unit

30 tablets/bottle, 300 tablets/bottle