Vesikyu Tablet 10 mg (Solifenacin Succinate)

Adult dose

The recommended dose for adults (including elderly patients) is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment: No dose adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30ml/min). Use with caution in patients with severe renal impairment (creatinine clearance≤30ml/min), and do not exceed 5mg once daily. 2. Patients with hepatic impairment: No dose adjustment is necessary in patients with mild hepatic impairment. Use with caution in patients with moderate hepatic impairment (Child-Pugh class B), and do not exceed 5mg once daily. 3. Patients receiving strong cytochrome P450 3A4 (CYP3A4) inhibitors: Limit the maximum daily dose to 5mg in patients receiving ketoconazole or other strong CYP3A4 inhibitors (e.g., ritonavir, nelfinavir, itraconazole).

This drug should not be used in patients with urinary retention or severe gastrointestinal disorders such as toxic megacolon. Additionally, it should not be administered to patients with myasthenia gravis, angle-closure glaucoma, known hypersensitivity to this medication, patients undergoing hemodialysis, and those with severe liver or kidney impairment. This drug contains lactose, so it should not be used in patients with lactose intolerance or related genetic issues. Caution should be exercised when administering to patients at risk of urinary retention, gastrointestinal obstruction, or those with severe renal impairment or moderate liver impairment. Dose adjustments may be necessary when co-administered with strong CYP3A4 inhibitors. Side effects may include dry mouth, constipation, blurred vision, urinary retention, and dry eyes; rare but serious adverse reactions such as angioedema or severe gastrointestinal reactions can also occur. This medication may affect driving or operating machinery, so caution is advised, especially if drowsiness or blurred vision occurs. Additionally, using this drug with other anticholinergic medications may enhance effects or exacerbate side effects, so a consultation with a physician is recommended. The safety of this drug during pregnancy has not been established, and it should only be used cautiously when necessary; during breastfeeding, it is recommended to avoid use as it may be excreted in breast milk. Safety and efficacy in children have not been established, so it should not be administered to pediatric patients. In case of overdose, symptoms such as headache, dizziness, drowsiness, and blurred vision may occur, and immediate medical consultation is required for appropriate treatment. Special caution is necessary for patients with heart disease or those at risk of QT prolongation, and any adverse reactions during medication use should be immediately reported to a healthcare institution for treatment.

• dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• nausea
• indigestion
• upper abdominal pain
• vomiting
• urinary tract infection

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. The recommended storage temperature is between 1°C and 30°C at room temperature. Proper storage will help maintain the drug's efficacy and safety over time.

Appearance

Bright pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle