Olzapex 10 mg Tablets (Olanzapine)

Adult dose

The therapeutic dose of this drug should be adjusted according to the patient's clinical condition. Increases above the usual recommended daily dose of 10 mg are recommended only after an appropriate clinical evaluation. Adults Schizophrenia: The recommended initial dose is 5∼10 mg of olanzapine once daily. Maintenance treatment of schizophrenia: Efficacy was demonstrated in a placebo-controlled study in patients with schizophrenia whose symptoms had stabilized after taking this drug for approximately 8 weeks and who received maintenance treatment at doses of 10∼20 mg daily for 8 months. The need for maintenance treatment at an appropriate dose should be assessed periodically. Treatment of manic and mixed episodes associated with bipolar I disorder: The initial dose is 15 mg of this drug once daily as monotherapy, or 10 mg once daily as adjunctive therapy with lithium or valproate. Prevention of recurrence in bipolar disorder: The recommended initial dose is 10 mg once daily. For patients who have been receiving this drug to treat mania, continue the same dose to prevent recurrence. If a new manic, mixed, or depressive episode occurs, continue this drug, together with adjunctive treatment for mood symptoms as clinically indicated (optimizing the required dose). Treatment of schizophrenia and manic and mixed episodes associated with bipolar I disorder, and prevention of recurrence in bipolar disorder: The daily dose may be adjusted within the range of 5 mg to 20 mg based on the clinical condition. Increases above the recommended initial dose are recommended only after an appropriate clinical evaluation and should generally be made at intervals of at least 24 hours. If treatment with this drug is discontinued, the dose should be reduced gradually and cautiously. Acute treatment of depressive episodes associated with bipolar I disorder: Begin treatment with 5mg of olanzapine once daily, then increase to 10mg once daily. Administer this drug at bedtime and adjust the dose as appropriate according to age and symptoms; do not exceed a daily dose of 20mg. Older adults: Starting at a dose of 5 mg or less daily may be considered when there is sufficient evidence based on clinical factors. Patients with renal or hepatic impairment: A low initial dose (5 mg) should be considered. In patients with moderate hepatic impairment (cirrhosis, Child-Pugh class A or B), the initial dose is 5 mg and should be increased cautiously. Patients with multiple factors that delay the metabolism of this drug (female sex, older age, and nonsmoking status) may also be started at a lower dose. Food does not affect drug absorption; therefore, this drug may be administered without regard to meals.

This medication can cause serious side effects, such as neuroleptic malignant syndrome, which can be life-threatening. If symptoms such as high fever, muscle rigidity, or changes in mental status occur, medication use should be immediately stopped and medical consultation should be sought. This medication is not approved for the treatment of psychosis or behavioral disorders associated with dementia, and caution is needed as it may increase the risk of mortality and cerebrovascular accidents particularly in elderly patients. Long-term use can lead to tardive dyskinesia, so dosage adjustment or discontinuation should be considered if symptoms appear. New or worsening diabetes or hyperglycemia may occur, so regular monitoring of blood glucose and weight is required, and any unusual symptoms should be reported to healthcare personnel. This medication may affect liver function, so patients with liver disease or elevated liver enzymes need regular liver function tests. Drowsiness or dizziness may occur during treatment, so caution is advised when driving or operating dangerous machinery. Women who are pregnant or breastfeeding should consult a doctor before use as it may affect the fetus or newborn. Serious side effects may occur with overdose, so it is critical to adhere to the prescribed dosage, and emergency medical attention should be sought if unusual symptoms arise. This medication may interact with certain drugs, so it is essential to inform healthcare professionals of any other medications being taken. Sudden discontinuation can result in symptoms such as insomnia, anxiety, and nausea, so it should be gradually reduced according to the doctor's guidance.

• High fever
• muscle rigidity
• changes in mental state
• irregular pulse
• changes in blood pressure
• tachycardia
• sweating
• cardiac arrhythmia
• elevated creatine phosphokinase
• myoglobinuria

This medication should be stored in a tightly sealed container to prevent air intrusion and kept in a cool place between 15 and 30 degrees Celsius. Proper storage helps maintain the effectiveness of the medicine for a longer period.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle