Coxren Capsule (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient, and it may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment with 400 mg per day, another treatment option should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment onward, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be taken with caution by those who regularly consume three or more glasses of alcohol per day, as it may lead to gastrointestinal bleeding. This medication may increase the risk of serious cardiovascular adverse events, myocardial infarction, and stroke, so it should be used at the lowest effective dose for the shortest duration possible. If symptoms such as chest pain, shortness of breath, weakness, or slurred speech appear during use, immediately inform medical personnel. This medication can cause serious gastrointestinal adverse reactions such as perforation, ulcers, and bleeding, particularly in elderly patients or those with a history of gastrointestinal disorders. If symptoms such as epigastric pain, indigestion, dark stools, or hematemesis occur, immediate evaluation and treatment by a healthcare facility is necessary. This medication should not be used in patients with certain allergies, severe liver or kidney impairment, active peptic ulcers, a history of heart failure or cardiovascular disease, or pregnant or breastfeeding women. Caution is required when prescribing to patients with compromised liver or kidney function, asthma, hypertension, or diabetes, with regular testing and monitoring needed. Dizziness or drowsiness may occur when taking this medication, so it is advisable to avoid driving or operating machinery. This medication may interact with other drugs, so if you are taking any other medications, be sure to inform your healthcare provider, especially with antihypertensives, anticoagulants, antidepressants, and immunosuppressants. Women who are pregnant or planning to become pregnant should avoid using this medication, and if pregnancy is confirmed while taking it, it should be discontinued immediately. Long-term use of this medication may affect liver and kidney function, requiring regular blood tests and monitoring of liver and kidney function. If hypersensitivity reactions such as skin rashes, blisters, fever, or itching occur, discontinue use immediately and consult a healthcare professional. In case of overdose, symptoms such as nausea, vomiting, lethargy, and drowsiness may occur, and appropriate treatment should be sought immediately. The safety and efficacy of this medication in children have not been established, and special caution is needed in the elderly due to the potential for compromised kidney and liver function. When storing, keep out of reach of children, and do not transfer to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, visual disturbances, cataract, conjunctivitis, eye pain, glaucoma, intraocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal impairment, acute renal failure, interstitial nephritis, headache, leg cramps, tension, sensory decline, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, exacerbation of allergies, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, angioedema, loss of appetite, increased appetite, depression, nervous hypersensitivity, drowsiness, fatal intracranial hemorrhage, hallucinations, epilepsy exacerbation, upper respiratory tract infection, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorder, vaginal bleeding, vaginitis, prostate disorder, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, hepatic failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthritis, skeletal abnormalities, myalgia, neck tension, synovitis, tendinitis, myositis, fracture, tendon rupture, pain in the back, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, phlegmon, contact dermatitis, injection site reaction, skin nodules, visual disturbances, cataract, conjunctivitis, eye pain, glaucoma, intraocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal impairment, acute renal failure, interstitial nephritis, anaphylactic reaction, hallucinations, intracranial hemorrhage, aseptic meningitis, loss of taste, loss of smell, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, hepatic failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, phototoxic reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, generalized fixed drug eruption, fixed drug eruption, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change disease.

This medication should be stored in a sealed container to prevent air ingress, and kept in a cool place between 15 to 30 degrees Celsius. This storage method can help maintain the medication's effectiveness.

Appearance

A white capsule filled with white to light yellow powder with yellow stripes on the top and bottom

Package unit

30 capsules/bottle, 100 capsules/bottle