Nobsetin Capsule 10 mg (Fluoxetine Hydrochloride)

Adult dosage

Depression Initial treatment: The initial dose is fluoxetine hydrochloride 20mg orally once daily in the morning. Doses of 20～80mg per day were used in controlled clinical trials. If improvement is not observed, an increase in dose may be considered after several weeks. Doses exceeding 20mg per day should be administered twice daily (morning and noon), and the maximum dose of 80mg per day should not be exceeded. The onset of an adequate antidepressant effect may be delayed until 4 weeks of treatment or later. Maintenance/continuation/extended treatment: There are no definitive data on how long patients should be treated with this medicine; however, psychopharmacologists agree that acute episodes of depression require several months or more of drug therapy. It is not known whether the amount of antidepressant needed to relieve symptoms is the same as that needed to maintain or sustain stability. Bulimia nervosa Administer 60mg of this medicine daily. The daily dose should not exceed 80mg. Measure electrolyte levels before starting treatment. Obsessive-compulsive disorder Administer 20～60mg of this medicine daily. The daily dose should not exceed 80mg. Premenstrual dysphoric disorder Administer 20mg of this medicine daily. Reassess the need for continued treatment after 6 months of treatment. Patients with renal and/or hepatic impairment, patients receiving multiple medications, older adults, and patients with comorbidities: Administer a lower dose or reduce the frequency of administration. Adjust the dose appropriately according to age and symptoms. Switching from MAO inhibitors used to treat psychiatric disorders When discontinuing an MAO inhibitor used to treat psychiatric disorders and starting treatment with this medicine, allow an interval of at least 14 days. Conversely, at least 5 weeks must elapse after discontinuing this medicine before starting an MAO inhibitor to treat psychiatric disorders. Other MAO inhibitors, such as linezolid or methylene blue Patients receiving linezolid or intravenous methylene blue should not start treatment with this medicine because of the increased risk of serotonin syndrome. For patients requiring more urgent treatment of a psychiatric condition, including hospitalization and other interventional procedures, treatment should be considered. It may be necessary to urgently administer linezolid or intravenous methylene blue to a patient already receiving this medicine. If no alternative to linezolid or intravenous methylene blue is available and, for a particular patient, the benefits of treatment with linezolid or intravenous methylene blue are judged to outweigh the risk of serotonin syndrome, discontinue this medicine immediately and administer linezolid or intravenous methylene blue. Monitor the patient for symptoms of serotonin syndrome for 5 weeks after administration of linezolid or intravenous methylene blue, or for 24 hours after the last dose, whichever comes first. Treatment with this medicine may be restarted 24 hours after the last dose of linezolid or intravenous methylene blue. The risk associated with administration of methylene blue by non-intravenous routes (oral tablets or local injection), or with intravenous administration of this medicine at doses of 1mg/kg or less, is unclear. Nevertheless, clinicians should be aware of the possibility of emergency symptoms of serotonin syndrome with these uses.

This medication is mainly used to treat mental health issues such as depression. Caution is necessary as the risk of suicidal thoughts or actions may increase, especially in children, adolescents, and young adults while taking this medication. Patients who are allergic to this medication, have severe renal impairment, or are currently taking certain medications such as MAO inhibitors should not use this medication. Patients with a history of seizures should use this medication cautiously and discontinue treatment immediately if seizures occur or worsen. If there are any changes in mental status such as suicidal thoughts or actions, aggression, anxiety, or insomnia, family members or caregivers should closely monitor and consult a physician. Patients with heart disease or those with abnormal electrocardiograms should have an electrocardiogram before taking this medication, and seek immediate medical attention if any heart-related symptoms occur during treatment. Patients with liver or kidney function impairment may require dose adjustments, and diabetic patients should frequently check blood glucose levels as this medication may affect blood sugar control. This medication can cause dilation of the pupils, and those with high intraocular pressure or a risk of glaucoma should use it carefully. Common side effects that may occur during treatment include headache, nausea, insomnia, fatigue, and diarrhea, while rare occurrences may include allergic reactions, cardiac arrhythmias, and bleeding. Discontinuation of this medication suddenly may result in withdrawal symptoms such as dizziness, anxiety, headache, and nausea, so it should be tapered off according to a physician's instructions. During pregnancy, there is a potential risk to the fetus, so it should only be used when absolutely necessary, and caution is needed during breastfeeding as the medication may be transmitted through breast milk. Safety in children and adolescents has not been adequately established, and therefore, the use of this medication is not recommended. This medication may interact with other drugs, so it is essential to inform the physician or pharmacist of any other medications being taken. Alcohol consumption is not recommended, and caution is required when driving or operating hazardous machinery. This medication should be stored out of reach of children, and it is best to avoid changing the storage container.

Headache, nausea, insomnia, fatigue, diarrhea, anaphylactic reactions, serum sickness, abnormal secretion of antidiuretic hormone, decreased appetite, hyponatremia, anxiety, nervousness, restlessness, tension, decreased libido, sleep disorders, abnormal dreams, depersonalization, elevated mood, feeling happy, thought disorders, abnormal libido, bruxism, hypomania, mania, hallucinations, agitation, panic attacks, suicidal impulses and behaviors, confusion, attention deficit, dizziness, taste disturbances, somnolence, drowsiness, tremors, psychomotor agitation, movement disorders, ataxia, balance disorders, paroxysmal muscle contractions, seizures, inability to sit still, buccoglossal syndrome, serotonin syndrome, memory disturbances, blurred vision, pupil dilation, palpitations, ventricular arrhythmia, QT prolongation, flushing, hypotension, vasculitis, vasodilation, yawning, dyspnea, pharyngitis, lung-related incidents, epistaxis, vomiting, dyspepsia, dry mouth, dysphagia, esophageal pain, gastrointestinal bleeding, specific hepatitis, rash, urticaria, pruritus, hyperhidrosis, hair loss, tendency for bruising, cold sweats, angioedema, petechiae, photosensitivity reactions, purpura, erythema multiforme, arthralgia, myoclonus, myalgia, increased frequency of urination, dysuria, urinary retention, voiding disorders, gynecological bleeding, erectile dysfunction, ejaculation disorders, sexual dysfunction, galactorrhea, hyperprolactinemia, priapism, anxious mood, chills, fatigue, abnormal mood, feeling cold, feeling hot, mucosal bleeding, weight loss, abnormal liver function tests, fractures, dizziness, sensory disturbances, sleep disorders, asthenia, agitation, anxiety, tremors, headache, anaphylactic-like reactions, gradual systemic reactions, severe skin, kidney, liver, or lung-related reactions, suicidal thoughts, suicidal behaviors, petechiae, purpura, vaginal bleeding, aggressive behavior, aplastic anemia, atrial fibrillation, cataracts, cerebrovascular accidents, cholestatic jaundice, movement disorders, eosinophilic pneumonia, epithelial necrosis, erythema multiforme, nodular erythema, exfoliative dermatitis, gynecomastia, cardiac arrest, liver failure, necrosis, hyperprolactinemia, hypoglycemia, immune-related hemolytic anemia, renal failure, movement disorders, optic neuritis, pancreatitis, pancytopenia, pulmonary embolism, pulmonary hypertension, thrombocytopenia, thrombocytopenic purpura, ventricular tachycardia, vaginal bleeding

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, ideally at a cool room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer time.

Appearance

Hard capsules with a powder filled that is white to grayish-white in color, with green upper and lower parts.

Package unit

30 capsules/bottle, 300 capsules/bottle