Clarithromycin 250 mg Tablets

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, administer in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer this medicine 500mg (potency) three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years of age and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be used in certain patients. Patients with allergies to this medication's components or with a history of hypersensitivity to similar antibiotics should not take it. Additionally, patients with specific heart conditions, severe liver disease, significantly impaired kidney function, pregnant or breastfeeding women, and those taking particular medications should not use this drug. This medication can be affected by liver and kidney functions, so it should be used cautiously in patients with liver disease or renal failure. Patients with heart conditions should also be cautious, as it may cause arrhythmias or other cardiac issues. Elderly patients and those taking other antibiotics should be especially careful. During treatment with this medication, rare allergic reactions, gastrointestinal issues, skin rashes, neurological symptoms, liver and kidney dysfunction, and hearing impairments may occur. If severe allergic reactions, skin abnormalities, persistent diarrhea, abdominal pain, or difficulty breathing arise, stop taking the medication immediately and consult a healthcare professional. This medication has many drug interactions, and co-administration can alter drug concentrations or increase the risk of side effects, so all current medications should be disclosed to healthcare providers. Special caution is necessary when taken with drugs affecting the heart, liver metabolism, blood sugar-lowering agents, anticoagulants, certain antiviral medications, etc. It is safest not to use this medication during pregnancy or breastfeeding unless absolutely necessary, and in such cases, consult a physician. For children, the safety and efficacy of this medication have been limitedly studied, so it is generally advised not to use it in children under 12 years old. Elderly patients may experience increased drug concentrations due to reduced kidney function, so dose adjustments may be necessary. Taking this medication for extended periods or in excess may lead to hearing impairment or other side effects, so adhere strictly to the prescribed dosage and administration guidelines. Finally, while taking this medication, symptoms such as dizziness or confusion may occur during driving or operating machinery, so caution is required.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, hives, skin redness, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle spasms, musculoskeletal rigidity, myopathy, elevated blood urea, phlebitis at the injection site, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication may be sensitive to light, so it should be stored in a dark place away from direct sunlight. It is recommended to maintain storage temperatures between 1 and 30 degrees Celsius at room temperature. Additionally, store the medication in a tightly sealed container to prevent air and moisture from entering.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle