Samjin Metformin Tablet (Metformin Hydrochloride)

Adult dose

The administration dose should be determined based on individual drug efficacy and tolerance, without exceeding the recommended maximum dose per day. Start with a low dose, administering 500 mg 2 to 3 times a day with meals. Dose increases should be gradual at 500 mg per week, and when dosing up to 2000 mg, it is usually divided into two doses in the morning and evening. If the dosage exceeds 2000 mg, it should be divided into three doses per day.

Child dose

For children over the age of 10 and adolescents in growth, the general starting dose is 500 mg once daily taken during or after meals. After one week, blood sugar levels should be measured to adjust the dosage.

This drug can cause severe lactic acidosis or hypoglycemia, so caution is needed. It should not be administered to patients with moderate to severe renal impairment, dehydration, or acute conditions such as severe infection or acute myocardial infarction. It is also not administered to patients with acute and unstable heart failure, those scheduled for tests using iodine contrast media, patients with hypersensitivity to this drug, or patients with type 1 diabetes. Patients with severe infections or traumatic systemic disorders should temporarily discontinue this drug, and those scheduled for surgery should also stop it 48 hours prior to the surgery and should only resume it after confirming normal kidney function. Patients with liver dysfunction, pulmonary embolism, severe lung function impairment, excessive alcohol consumption, or malnourished state should also use this drug with caution. Patients with irregular meals, insufficient food intake, vigorous exercise, or those taking interacting drugs should be monitored carefully due to the risk of lactic acidosis and hypoglycemia. Various adverse reactions such as gastrointestinal discomfort, metallic taste, skin rash, anemia, liver dysfunction, and hypoglycemia may occur with this drug, so symptoms should be promptly discussed with medical personnel. Kidney function should be regularly monitored, especially in elderly patients or those with impaired renal function, who need to be monitored more frequently. Alcohol can affect the metabolism of lactate from this drug, increasing the risk of lactic acidosis, so excessive alcohol consumption should be avoided. During pregnancy, limited reports indicate effects on the fetus, but it should not be administered in cases of placental insufficiency or risk of preeclampsia. During breastfeeding, this drug is excreted in breast milk, so the necessity of treatment and the decision to breastfeed should be carefully considered. This drug can interact with other hypoglycemic agents or various medications, so blood glucose and patient condition should be closely monitored during combination therapy. In case of overdose, blood dialysis is possible for drug removal, so prompt treatment is necessary. It is important to continuously monitor blood glucose and kidney function during the treatment with this drug.

Serious side effects

Lactic acidosis, severe allergic reactions (such as rash), serious skin reactions, hypoglycemia (severe delayed hypoglycemia), liver issues (potential liver dysfunction and jaundice), severe edema, severe neurological symptoms, respiratory problems

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal distension, loss of appetite, dyspepsia, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver dysfunction, hypoglycemia

This drug should be kept in a tightly sealed container to prevent air exposure and stored at room temperature between 1 degree and 30 degrees Celsius. Proper storage helps maintain the drug's effectiveness.

Appearance

White round film-coated tablet

Package unit

500 tablets/bottle