Celsive Capsule 200 mg (Celecoxib)

Adult dosage

The minimum recommended dose of this medicine should be adjusted for each patient. It may be taken regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks at 400 mg daily, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose as needed is 200 mg per dose twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may pose a risk of gastrointestinal bleeding if taken by individuals who regularly consume three or more alcoholic drinks per day, so it should be discussed with a doctor or pharmacist. This medication may increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, and should only be used at the lowest effective dose for the shortest duration possible, with careful monitoring for any cardiovascular symptoms. This medication can increase the risk of serious gastrointestinal adverse reactions such as perforation, ulcer, and bleeding, so caution is particularly needed for elderly patients or those with a history of gastrointestinal disorders. This medication contains sulfonamide components, so it should not be used by patients with hypersensitivity or related allergies. Administration is contraindicated in certain patient populations such as those with severe liver impairment, severe kidney impairment, active peptic ulcer, heart failure, ischemic heart disease, pregnant women, and nursing mothers. Some patients with liver impairment, kidney impairment, asthma, hypertension, heart failure, and elderly patients should use this medication cautiously and carefully monitor their condition during treatment. This medication can cause various adverse reactions, including dyspepsia, headache, dizziness, hypertension, gastrointestinal bleeding, hepatic dysfunction, skin rash, peripheral edema, facial swelling, influenza-like illness, thrombocytopenia, tinnitus, palpitations, dry mouth, stomatitis, dental disorders, upper respiratory infection, sinusitis, pharyngitis, rhinitis, bronchitis, asthma attacks, laryngitis, pneumonia, angioedema, alopecia, and blood disorders (anemia, thrombocytopenia, etc.), and menstrual disorders. Long-term use requires regular blood tests and liver/kidney function tests, and any unusual symptoms should prompt immediate consultation with medical personnel. This medication may interact with other drugs, so it's important to inform healthcare providers about any other medications being taken, especially when used in combination with anticoagulants, diuretics, antihypertensives, and antidepressants. Pregnant women or women of childbearing potential should not take this medication, and those who are breastfeeding should also avoid it if possible. Elderly patients may have reduced liver and kidney function, requiring extra caution while taking this medication and possible dose adjustments if necessary. In case of overdose, symptoms like nausea, vomiting, drowsiness, and gastrointestinal bleeding may occur, requiring immediate medical intervention. This medication should be kept out of reach of children and should not be transferred to other containers as this can adversely affect the quality.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, hemorrhage, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disorders, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, pruritus, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial swelling, influenza-like illnesses, trauma, headache, leg cramps, tension, sensory reduction, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, ageusia, allergy exacerbation, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, loss of appetite, increased appetite, depression, nervous hyper-responsiveness, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infections, sinusitis, pharyngitis, rhinitis, bronchial spasms, exacerbation of bronchial spasms, dyspnea, laryngitis, pneumonia, nosebleeds, voice disorders, vesicular dermatitis, dermatitis, nail disorders, photosensitivity reactions, itching, erythematous rash, maculopapular rash, skin disorders, skin dryness, increased sweating, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, eczema, lipomas, allergic dermatitis, petechiae, dandruff, drug rash with eosinophilia and systemic symptoms, arrhythmia, ventricular hypertrophy, angina, unstable angina, coronary artery disease, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral necrosis, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, herpes simplex, wound infections, gingivitis, herpes zoster, bacterial infections, fungal infections, soft tissue infections, viral infections, candidiasis, genital candidiasis, otitis media, mastalgia, menopausal symptoms, fibrocystic breast disease, chest tumors, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urine bilirubin, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, fractures, tendon rupture, back pain, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, folliculitis, contact dermatitis, injection site reactions, dermal nodules, taste disturbances, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, visual blurriness, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, female infertility, chest pain, anaphylactic reactions, hallucinations, cerebral hemorrhage, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, bile duct obstruction, obstructive cholangitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change disease.

This medication should be stored in a tightly sealed container to prevent air and moisture ingress. It is best to maintain a storage temperature between 15 and 30 degrees Celsius.

Appearance

A white to off-white powder filled in a white capsule.

Package unit

30 capsules/bottle, 100 capsules/bottle