Alzepil Tablets 10mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer 5 mg of donepezil hydrochloride once daily at bedtime. If sleep disturbances such as abnormal dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. Since donepezil concentrations reach steady state after 15 days of administration and the incidence of adverse reactions may be affected by the rate of dose escalation, maintain the 5 mg dose for 4~6 weeks. After assessing the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. If treatment with this medicine is discontinued, its effects gradually diminish; no rebound effect occurs with abrupt discontinuation. ○ Women aged 85 years and older with low body weight: Adverse reactions occur more frequently, so careful monitoring is required. Older women with low body weight should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medicine contains the ingredient donepezil hydrochloride and is primarily used for the treatment of symptoms of Alzheimer's dementia. First, this medication should not be used in certain patients. For example, individuals with an allergy to this medication or its ingredients, pregnant women or women who may become pregnant, and nursing mothers should not take this medication. Also, patients with genetic lactose metabolism issues should avoid this medication. Patients with heart disease or heart conduction disorders, those with a history of peptic ulcers or who are taking non-steroidal anti-inflammatory drugs, patients with asthma or a history of obstructive pulmonary disease, and patients with extrapyramidal disorders such as Parkinson's disease should exercise caution when using this medication. People allergic to Yellow No. 4 (Tartrazine) included in this medication should also use it cautiously. Possible side effects that can occur while taking this medication include heart-related problems (bradycardia, heart block, myocardial infarction, etc.), gastrointestinal issues (peptic ulcers, gastrointestinal bleeding), liver function abnormalities, brain-related problems (cerebral hemorrhage, seizures), motor function disorders, respiratory distress, acute pancreatitis, acute renal failure, and sudden death. Common side effects include nausea, vomiting, diarrhea, dizziness, insomnia, loss of appetite, and may rarely include serious neurological symptoms. This medication can particularly affect the heart, potentially causing bradycardia or arrhythmias, so patients with heart conditions should have regular electrocardiographic examinations. Additionally, it may burden the gastrointestinal system, so patients with a history of peptic ulcers should carefully monitor their symptoms. Caution is required when driving or operating machinery due to potential side effects such as fatigue, dizziness, and muscle cramps resulting from this medication. This medication may interact with other drugs, so it is essential to consult with a doctor or pharmacist, especially when taken in combination with specific antibiotics, antidepressants, antiarrhythmics, heart-related medications, and other cholinergic drugs. Pregnant or nursing women are advised not to use this medication and should consult a specialist before use if absolutely necessary. Safety for children has not been established, so it should not be used in pediatric patients. In cases of overdose, severe nausea, vomiting, sweating, bradycardia, hypotension, respiratory distress, and seizures may occur, and immediate medical attention should be sought. Finally, this medication should be stored out of reach of children and kept in its original packaging.

• Syncope
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is safe to store at room temperature between 1°C and 30°C. Storing it this way helps maintain the efficacy of the medication and prevents deterioration.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle