Cramon Neo Syrup (Amoxicillin Hydrate - Clavulanate Potassium)

Child dose

For pediatric patients over 3 months: Based on amoxicillin content (600 mg/5 mL), 90mg/kg/day is divided into doses every 12 hours. For acute otitis media, it is taken for 10 days; for acute sinusitis, it is taken for 7 days.

This medicine contains a beta-lactam antibiotic and includes components from the penicillin group. It should not be administered to patients who have hypersensitivity to the ingredients or a history of allergy to beta-lactam antibiotics. Use in patients with specific viral infections, such as infectious mononucleosis or lymphocytic leukemia, may increase the risk of side effects like skin rashes. Patients with a history of liver dysfunction or jaundice should be cautious, as this medication may worsen their symptoms. This medication contains lactose, hence it should not be given to patients with lactose intolerance or galactose metabolism disorders. In patients with liver impairments or severe renal impairments, careful use is required, and dosing intervals should be adjusted as the drug concentration may increase. Patients with allergic constitutions or who easily exhibit hypersensitivity reactions, like asthma or urticaria, should be careful when using this medication. Patients who have difficulty swallowing, are elderly, or have poor general health may exhibit symptoms of vitamin K deficiency; caution should be exercised. Patients with gastrointestinal diseases may have reduced absorption of this medication, so their condition should be checked before administration. This medicine is generally well tolerated, but side effects such as diarrhea, vomiting, skin rashes, and contact dermatitis may occur. In severe cases, symptoms like pseudomembranous colitis, hepatitis, severe skin reactions, blood abnormalities, and renal function impairment may arise; if any unusual symptoms occur, the medication should be stopped immediately and a physician consulted. Since this is a penicillin-class antibiotic, severe allergic reactions, like anaphylactic shock, may rarely occur; patients should be closely monitored after administration. Prolonged use may carry a risk of resistant strains developing, so it is important to administer only for the minimum necessary duration after sensitivity testing. It is advisable to avoid this medication during pregnancy, particularly in the first three months, and caution should be observed during breastfeeding, as a small amount may be excreted into breast milk, leading to side effects in infants. Safety and efficacy have not been established in infants under three months of age; thus, it should not be administered. This medicine may interact with other medications; care should be taken when coadministering with anticoagulants, probenecid, allopurinol, etc. In the case of overdose, gastrointestinal symptoms, renal damage, and seizures may be observed; immediate discontinuation and appropriate treatment are necessary. This medication should be stored in a refrigerated condition after preparation and used within seven days, keeping out of reach of children. Before use, the medication should be shaken well to ensure uniformity.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, mucosal pain in mouth/eyes, shortness of breath or difficulty breathing, asthmatic attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination issues

Mild side effects

Contact dermatitis, diarrhea, vomiting, moniliasis, rash, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, loss of appetite, abdominal pain, abdominal distention, constipation, colonic pain, acidity, loose stools, dry mouth, elevated AST, ALT, ALP, LDH, increased serum bilirubin, hepatitis, cholestatic jaundice, itching, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, vesiculobullous dermatitis, acute generalized exanthematous pustulosis, fever

This medication should be stored in a sealed container to protect it from air and moisture. Furthermore, it should be kept in a cool, dry place below 25 degrees Celsius to maintain its efficacy.

Appearance

A white or light yellow powder that is dissolved before use as syrup

Package unit

50 milliliters