Denyrin Granules 0.1 mg (Desmopressin Acetate)

Adult dose

Treatment of nocturia associated with nocturnal polyuria (adults only) Administer desmopressin acetate 0.1mg orally at bedtime. If the effect is insufficient after one week, increase the dose to 0.2mg; if the effect remains insufficient, the dose may be increased at weekly intervals up to 0.4mg. Discontinue treatment if there is no clinical effect within 4 weeks after determining the dose.

Child dose

Primary nocturnal enuresis (age 5 years and older): Administer desmopressin acetate 0.2mg orally at bedtime. If the effect is insufficient, the dose may be increased to 0.4mg. Whether to continue treatment should be determined after 3 months of administration, following a treatment-free period of at least 1 week.

This medication helps regulate fluid balance in the body. However, in elderly patients or those with certain conditions, there is a risk of excessive fluid retention leading to hyponatremia or water intoxication, so water intake should be restricted to thirst only. This medication should not be used by patients with allergies to its components or those with certain kidney diseases, heart failure, or habitual enuresis. Caution should be exercised in patients with high blood pressure, cardiovascular diseases, pregnant women, children, the elderly, or those with electrolyte imbalances. Severe side effects such as headache, nausea, weight gain, and coma may occur, so if symptoms arise, medical consultation should be sought immediately. Fluid intake should be restricted from 1 hour before administration until 8 hours after administration, and caution is required as the restriction time may vary depending on kidney function. Especially in the elderly, the risk of hyponatremia is high, so sodium levels should be frequently monitored through blood tests before and during treatment. This medication may interact with other drugs; therefore, if taking other medications, it is important to inform the doctor or pharmacist. Women who are pregnant or breastfeeding should carefully consider the effects on the fetus or newborn when using this medication, and it is recommended to stop breastfeeding if using this medication. In case of overdose, symptoms such as headache, seizures, and loss of consciousness may occur, requiring immediate medical attention for appropriate treatment. This medication does not affect driving or operating machinery, but caution is required in case of side effects.

• consciousness disturbance
• seizures
• weight gain
• hyponatremia
• allergic reactions
• emotional disorders
• headache
• abdominal pain
• nausea
• allergic skin reactions

This medication is susceptible to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius. This preserves the medication's effectiveness for a longer period.

Appearance

White or pale yellow granules

Package unit

1 packet (500 mg) X 30 packets/box