Cholestop Tablet 20mg (Rosuvastatin Calcium)

Adult dose

Administered once daily at any time regardless of meals. The initial dose is 5 mg once daily. If greater LDL cholesterol reduction is needed, the maintenance dose may be adjusted, with the maintenance dose being 10 mg once daily. The maintenance dose should be adjusted based on LDL cholesterol levels, treatment goals, and patient response, at intervals of at least 4 weeks, with a maximum possible dose of 20 mg per day.

Child dose

For pediatric patients aged 10 to 17 years, the dosage is administered once daily within the range of 5 mg to 20 mg. The dosage is adjusted according to each individual patient's treatment goals, typically with intervals of at least 4 weeks between adjustments.

This medication should not be used in certain patients. For example, it should not be administered to those with an allergy to its components, severe liver dysfunction, muscle diseases, patients taking certain immunosuppressants, patients with severe renal impairment, pregnant or breastfeeding women, and fertile women who do not use adequate contraception. Moreover, high doses of this medication are prohibited in patients prone to myopathy or rhabdomyolysis, and careful evaluation is required for patients with these risk factors before administration. This medication contains lactose and should not be used in patients with lactose intolerance or certain inherited metabolic disorders. Patients with a history of liver disease or those consuming alcohol excessively should undergo regular liver function tests before starting this medication and while on it. If patients have specific diseases such as hypothyroidism or nephrotic syndrome, those conditions should be treated prior to therapy. This medication may cause myalgia, myopathy, and rarely severe muscle damage, such as rhabdomyolysis; thus, if muscle pain or weakness occurs, patients should notify their physician immediately. Discontinuation of the medication is advised especially if markers of muscle damage are significantly elevated in blood tests. The medication should be stopped in case of acute severe illness or if severe muscle weakness develops, and some patients may experience serious side effects such as severe skin reactions, thus any abnormal skin symptoms should prompt immediate medical consultation. This medication may interact with various other drugs, so patients taking other medications must inform their doctor or pharmacist, especially caution is warranted when used in conjunction with certain antiviral medications, immunosuppressants, or fibrates. Women of childbearing potential must ensure proper contraception during treatment and should discontinue the medication immediately if pregnancy occurs. It is also advisable not to use this medication while breastfeeding. In case of overdose, there is no specific antidote, so symptomatic treatment should be administered, and liver function and muscle injury should be closely monitored. This medication can cause symptoms like dizziness, hence caution is advised during driving or operating machinery. Lastly, this medication may show higher body concentrations in Asians, necessitating dosage adjustments.

Serious side effects

Urticaria, angioedema, myopathy, rhabdomyolysis, severe muscle weakness, oculobulbar weakness, thrombocytopenia, jaundice, hepatitis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), immune-mediated necrotizing myopathy, acute renal failure, oliguria, chest discomfort, dyspnea, severe allergic reactions, severe skin adverse reactions, respiratory issues, liver abnormalities, serious neurological symptoms

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• hematuria
• diarrhea

This medication should be stored in a tightly sealed container to protect it from air and moisture. It should be kept away from excessively hot or cold places, preferably stored at room temperature, between 1 to 30 degrees Celsius.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle