Beaclareth 375 mg (Amoxicillin Trihydrate - Clavulanate Potassium)

Adult dose

Adults and children ages 12 and older or weighing 40 kg and above should take Amoxicillin/Clavulanate Potassium as 250 mg/125 mg orally three times a day every 8 hours, and for severe or respiratory infections, the dosage can be increased to 500 mg/125 mg at a time. In cases of renal impairment, the dosing should be adjusted based on creatinine clearance. - Creatinine clearance of 30 mL/min or more: No dosage adjustment required.

Child dose

Pediatric patients should receive a reduced dosage following the same method as adults.

This medication is a beta-lactam antibiotic and should not be administered to patients with allergies to penicillin drugs. Particularly, patients with infectious mononucleosis or lymphocytic leukemia are at higher risk of rash and require caution. Patients with liver dysfunction or a history of hepatitis should also be cautious when using this medication, as there is a possibility of exacerbating liver function. Patients with moderate to severe impaired kidney function may have prolonged drug retention in the body, requiring adjustments in dosing intervals. Patients with an allergic constitution or bronchial asthma, older adults, and those in poor general condition should be cautious as they may be at risk of bleeding due to vitamin K deficiency. This medication may cause gastrointestinal side effects such as diarrhea, abdominal pain, and vomiting; if severe diarrhea or abdominal pain occurs, treatment should be discontinued immediately and a doctor should be consulted. Liver dysfunction may occur, necessitating liver function tests in the case of prolonged use, especially as it may occur more frequently in men over 60. Serious skin reactions such as skin rashes, urticaria, and in severe cases, Stevens-Johnson syndrome may occur; discontinue use immediately if symptoms arise. Blood tests occasionally report abnormalities such as leukopenia and thrombocytopenia, thus regular blood testing is recommended. Central nervous system symptoms may rarely include headache, dizziness, and seizures; caution is advised in patients with poor kidney function due to increased seizure risk. This medication can interact with other drugs, especially anticoagulants, allopurinol, and disulfiram, thus caution is necessary when taken together. Pregnancy should be avoided in the first three months, and pregnant or nursing women should use it cautiously after consulting a doctor. Use in children under 12 years or below 40 kg of weight is not recommended due to limited experience. Older adults may experience adverse reactions more easily due to decreased kidney and liver function, and monitoring of dosages and intervals should be performed accordingly. In cases of overdose, gastrointestinal symptoms, rashes, and seizures may occur; treatment should be discontinued immediately, and appropriate care should be received. Storage should be in a sealed container to prevent moisture, and it is important to maintain a cool temperature between 1 and 25 degrees Celsius during storage. This will help safely maintain the medication’s efficacy over time.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, paleness, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, respiratory problems, yellowing of the skin or eyes (jaundice), profound fatigue, liver abnormalities (jaundice), sudden...

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This medication should be kept in a sealed container to prevent moisture, and it is important to maintain a cool temperature between 1 and 25 degrees Celsius during storage. This will help to safely preserve the drug's efficacy for a long time.

Appearance

Oval-shaped film-coated tablet, white or almost white

Package unit

100 tablets (10 tablets/PTP x 10)