HURESTO Tablet 10 mg (Rosuvastatin Calcium)

Adult dose

Administer 5 mg once daily at any time, regardless of meals. If further LDL cholesterol reduction is required, maintain a dosage of 10 mg once daily, and adjust as needed based on LDL cholesterol levels, treatment goals, and patient's response at intervals of 4 weeks or more. The maximum daily dosage can be increased up to 20 mg.

Child dose

For pediatric patients aged 10 to 17 with heterozygous familial hypercholesterolemia, the starting dosage is 5 mg to 20 mg once daily, with the dosage adjusted individually. Dosage adjustments should be made at intervals of 4 weeks or more.

This medication should not be taken by certain patients. For instance, individuals with an allergy to this medication, patients with severe liver dysfunction, muscular disorders, severe renal impairment, or women who are pregnant or breastfeeding should avoid using it. Additionally, this drug may cause muscle-related side effects, so caution should be exercised for patients who are at higher risk for myalgia or myopathy. In particular, dosage adjustments should be considered for patients with moderate to severe renal impairment, hypothyroidism, a family history of such disorders, individuals with a history of alcohol abuse, specific ethnic groups (Asian patients), and those taking fibrate drugs. This medication contains lactose, so individuals with lactose intolerance or related genetic conditions should not take it. Moreover, patients sensitive to yellow dye (Yellow No. 5) should use it cautiously. Patients with poor liver function or those who consume excessive alcohol should have liver function tests before taking this medication and have their liver enzyme levels monitored regularly. It is advisable for patients with hypercholesterolemia due to hypothyroidism or certain nephrotic syndromes to receive treatment for the underlying condition before using this medication. If symptoms such as muscle pain, muscle weakness, cramps, fatigue, or fever occur during treatment, medical attention should be sought immediately, and blood tests may be needed to check for muscle damage. In severe cases, discontinuation of therapy may be required, and if symptoms improve, re-initiation at a lower dose may be considered. This medication interacts with certain other medications, so patients taking other drugs must inform their doctor or pharmacist. In particular, co-administration with cyclosporine, fibrate-class drugs, niacin, and certain antibiotics and antifungals may increase the risk of muscle side effects. Women who are pregnant or may become pregnant should use appropriate contraception and discontinue use immediately if they become pregnant. Breastfeeding women should also avoid using this medication for safety. In case of overdose, as there is no specific antidote, treatment should be symptomatic, and liver function and muscle enzyme levels should be monitored. This drug does not significantly affect driving or operating machinery; however, caution is needed as symptoms such as dizziness may occur. Finally, this medication may rarely cause serious skin reactions, liver damage, kidney issues, or muscular diseases; thus, if unusual symptoms arise, consultation with medical personnel should be sought immediately.

Serious side effects

Urticaria, angioedema, Stevens-Johnson syndrome, eosinophilia and systemic symptoms drug reaction syndrome (DRESS), rhabdomyolysis, severe muscle weakness, ocular myasthenia, jaundice, hepatitis, severe allergic reactions, severe skin reactions, dyspnea, respiratory abnormalities with cough and fever, severe edema, urination abnormalities with hypertension, acute renal failure, oliguria, acute severe conditions (sepsis, hypotension, major surgery)

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• hematuria
• diarrhea

This medication should be kept in a tightly sealed container to prevent exposure to air and moisture. It is best stored at a temperature between 1 to 30 degrees Celsius.

Appearance

Pink, round film-coated tablets

Package unit

30 tablets (15 tablets/PTP x 2), 30 tablets/bottle, 100 tablets/bottle