Myungmoon Leflunomide Tablet 10mg

Adult dose

1. Loading dose In view of this medicine's long half-life and the recommended 24-hour dosing interval, treatment is generally initiated with a loading dose to achieve steady-state plasma concentrations more rapidly. Administer 100mg per dose, once daily for 3 days as the loading dose. In patients with rheumatoid arthritis, omitting the loading dose may reduce the risk of adverse reactions (see section ‘5. General Precautions 9)’). 2. Maintenance dose Administer 20mg once daily as the maintenance dose to patients with rheumatoid arthritis. When a dose of 25mg daily was administered, some patients experienced adverse reactions such as hair loss, weight loss, and elevated liver enzyme levels. Therefore, the maintenance dose should not exceed 20mg daily, and may be reduced to 10mg daily in patients with poor clinical tolerability. Administer 20mg daily as the maintenance dose to patients with psoriatic arthritis. Monitor liver enzyme levels; dose adjustment may be necessary. (See Warning - Hepatotoxicity.) Because the half-life of this medicine's active metabolite is prolonged, it may take several weeks for metabolite levels to decrease. Therefore, monitor patients carefully after reducing the dose.

This medication has an active metabolite that remains in the body for a long time, and adverse effects may occur or persist even after discontinuation. If serious adverse effects occur, rapid treatment to remove the medication may be necessary under specialist direction. This medication is metabolized and excreted by the liver, so patients with impaired liver function require special caution and should not use it if there is a history of liver damage. Liver function tests should be frequently monitored before and during medication, and if liver enzyme levels rise significantly, dosage adjustment or discontinuation may be necessary. This medication can suppress immune function and is not recommended for patients with serious immune deficiency or infections. Patients with a history of pulmonary disease or symptoms of pneumonia must receive medical evaluation before taking this medication, and respiratory symptoms should be monitored during use. Serious allergic reactions or ulcers may occur on the skin; if such symptoms occur, the medication should be stopped immediately, and medical advice should be sought. Women who are pregnant or may become pregnant should not take this medication, and if pregnancy is confirmed during use, immediate consultation with a physician is required. Patients with genetically lactose intolerance should not take this medication. Regular blood tests and liver function tests should be performed during medication, particularly for patients with bone marrow function suppression. This medication can increase the risk of adverse effects when used with other hepatotoxic drugs or immunosuppressants, so consultation with a physician is required. In case of overdose, symptoms such as diarrhea, abdominal pain, and blood abnormalities may occur, and treatment to remove the medication may be necessary. This medication should be stored in a container that blocks light below 25 degrees Celsius, and can be used for children or elderly patients without special dosage adjustments. This medication may increase sensitivity to infections due to its immunosuppressive action; if symptoms of infection appear, immediate consultation with healthcare professionals is necessary. Blood pressure should be regularly monitored during use, and if any unusual symptoms arise, immediate consultation with a physician is required. This medication can have severe effects on the fetus during pregnancy; therefore, women planning to become pregnant must consult with a physician before use.

• Diarrhea
• elevated liver enzymes (ALT, AST)
• hair loss
• rash
• hypersensitivity reactions
• asthenia
• flu-like syndrome
• upper respiratory infections
• injuries
• pain

This medication is sensitive to light and should be stored in a container that blocks light. Additionally, it is important to store it in a cool place below 25 degrees Celsius to maintain its efficacy.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle