Nexpra Tablet 20 Milligrams (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be swallowed with liquid such as water and should not be chewed or crushed. 1. Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. Patients whose esophagitis is not resolved or symptoms persist may take it for an additional 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily. - For treatment of gastroesophageal reflux disease symptoms without esophagitis: · 20 mg once daily. If symptoms remain unmanageable after 4 weeks, further consultation is required. · Once symptoms relieve, further continuous symptoms should be managed with 20 mg once daily. · In adults, 20 mg may be given as needed once daily. For patients at high risk of gastric ulcer and duodenal ulcer due to non-steroidal anti-inflammatory drug use, administration as needed for continuous symptom control is not recommended. 2) Combination therapy with antibiotics for Helicobacter pylori eradication Administer this medication 20 mg with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days. 3) Short-term therapy for upper gastrointestinal symptoms (pain, discomfort, burning sensation) related to the administration of non-steroidal anti-inflammatory drugs (non-selective COX-2, selective) - 20 mg once daily. If symptoms remain unmanageable after 4 weeks, further consultation is needed. Clinical trials exceeding 4 weeks have not been conducted. 4) For patients requiring continuous non-steroidal anti-inflammatory drug administration - Treatment of gastric ulcers associated with non-steroidal anti-inflammatory drug use: 20 mg once daily for a treatment duration of 4 to 8 weeks. - Prevention of gastric ulcers and duodenal ulcers associated with non-steroidal anti-inflammatory drug use: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. Subsequent doses should be adjusted according to the patient, and therapy should continue while clinical symptoms are present. According to clinical data, most patients are manageable at doses of 80 to 160 mg daily. Dosage above 80 mg daily should be divided into two doses. 6) Maintenance therapy following intravenous prevention of rebleeding from gastric ulcers or duodenal ulcers After intravenous prevention of rebleeding from gastric ulcers or duodenal ulcers, administer 40 mg once daily for 4 weeks.

Children's dosage

Adolescents 12 years and older 1. Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks - Symptomatic treatment without esophagitis: once daily, 1 dose

This medication should not be administered to certain patients. For example, patients with known allergies to this medication or its components, a history of hypersensitivity, those allergic to penicillin or macrolide antibiotics, patients taking certain heart-related medications, nursing women, or patients with a history of myocardial infarction should not use this medication. Additionally, caution should be exercised when administering this medication to patients allergic to Yellow 5 dye. There may be various adverse reactions when using this medication, so caution is needed. Commonly reported symptoms include headaches, abdominal pain, diarrhea, and constipation, while rare side effects may include blood abnormalities, allergic reactions, hypomagnesemia, psychiatric symptoms, liver dysfunction, skin rashes, and severe skin reactions. Prolonged use of this medication may mask symptoms of malignant tumors; therefore, diagnostic evaluations by a doctor and regular examinations are required. Furthermore, there may be an increased risk of fractures with long-term use, so patients at risk of osteoporosis should exercise caution. This medication may interact with other drugs, so it is essential to consult a doctor or pharmacist when used in conjunction with antibiotics, antiviral agents, anticoagulants, anticonvulsants, etc. During pregnancy, no specific harm was found in animal studies, but caution should be exercised when administering it to pregnant women, and nursing women should avoid using this medication. In case of overdose, there is no specific antidote, and treatment should be symptomatic; this medication is not removed by dialysis, necessitating caution. Lastly, it is important to keep this medication out of reach of children and not to transfer it to other containers to maintain quality.

Serious side effects

Urticaria, angioedema, anaphylaxis reaction/shock, hypomagnesemia, hypocalcemia, hepatitis, jaundice, liver failure, encephalopathy, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), rhabdomyolysis, severe allergic reactions, severe skin reactions, systemic lupus erythematosus, cutaneous lupus erythematosus

Mild side effects

Headache, dizziness, paresthesia, drowsiness, taste disturbance, blurred vision, dizziness, bronchospasm, abdominal pain, constipation, diarrhea, abdominal bloating, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, dermatitis, itching, rash, hair loss, photosensitivity, fractures, arthralgia, myalgia, muscle weakness, interstitial nephritis, gynecomastia, asthenia, increased sweating, clostridium difficile-associated diarrhea, allergic reactions, back pain, chest pain, sternum pain

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is between 1 and 30 degrees Celsius. This will help maintain the drug's effectiveness over time.

Appearance

Pale pink round film-coated tablet

Package unit

28 tablets (14 tablets/PTP x 2)