Aipolmin Sustained Release Tablets (Metformin Hydrochloride)

Adult dose

The typical initial dose is 500mg of metformin hydrochloride sustained release tablets once daily with the evening meal. After a week, blood sugar levels should be measured to adjust the dose. When increasing the dose, it should be increased by 500mg weekly, with a maximum daily dose of 2000mg to be taken with the evening meal. If blood sugar control is not achieved even after using the maximum dose of 2000mg once daily, consideration may be given to administering 1000mg twice daily with meals.

This medication can rarely cause a serious condition called lactic acidosis. Lactic acidosis occurs when there is an excessive build-up of lactic acid in the blood, leading to acidity that can be life-threatening if untreated. Caution is needed when using this medication in conjunction with other diabetes medications as hypoglycemia can occur, especially when combined with insulin or sulfonylureas, which may increase the risk of low blood sugar. Patients with moderate to severe renal impairment or those with dehydration, serious infections, and acute myocardial infarction should not use this medication. In such cases, the drug may accumulate in the body and pose risks. Additionally, patients with acute heart failure or those scheduled for tests using radiologic iodine contrast agents should avoid use. The use of contrast agents may worsen kidney function and increase the risk of lactic acidosis. Patients who have had an allergic reaction to this medication or similar drugs, those with type 1 diabetes, and those with diabetic ketoacidosis should also avoid using this medication. Before and after surgery, and in cases of severe infection or trauma when the patient's condition is poor, this medication should be temporarily discontinued, and resumed only after kidney function has recovered. Patients who are malnourished or have impaired liver function, as well as those who consume excessive alcohol, should also be cautious when using this medication. This medication may cause side effects such as gastrointestinal disturbances, taste changes, vitamin B12 deficiency, and especially in the initial treatment phase, nausea, vomiting, and diarrhea may occur. Most of these symptoms typically resolve over time. Regular monitoring of blood sugar levels is essential, as well as periodic assessments of kidney function. Older patients or those with weakened kidney function may require more frequent testing. During treatment, it is advisable to avoid acute or chronic excessive alcohol consumption, and because there can be interactions with other medications, patients should always consult their doctor or pharmacist about other medications they are taking. During pregnancy, this medication may affect the fetus, so those planning to become pregnant or who are pregnant should discuss its use with their doctor. This medication is not recommended for children under 17 years of age, as its safety and efficacy have not been confirmed in this population. In the event of an overdose, hypoglycemia is rare, but the drug may accumulate in the body, so medical attention should be sought immediately for proper treatment. Finally, this medication should be swallowed whole and not chewed or crushed, and the coating may sometimes appear in the stool, which is a normal occurrence.

Serious side effects

Lactic acidosis (frequently occurring in cases of acute renal failure, cardiopulmonary disease, and sepsis), severe allergic reactions (such as hives), severe edema related to dehydration, hypoglycemia, liver abnormalities (although jaundice symptoms are not specified, caution for liver dysfunction), respiratory issues (including difficulty breathing and weakness associated with lactic acidosis symptoms)

Mild side effects

• Vitamin B12 deficiency
• taste impairment
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is advisable to keep the storage temperature between 1°C and 30°C room temperature. This way, the effectiveness and safety of the medication can be maintained for a longer period.

Appearance

White rectangular tablets

Package unit

30 tablets/bottle, 300 tablets/bottle