Dairyl Tablet (Glimepiride)

Adult dose

Adjusted individually for each patient. This medication is taken orally once a day, before breakfast or immediately prior to the first meal. Start with a dose of 1 mg of glimepiride once daily and may increase the dose by 1 mg at intervals of 1 to 2 weeks. Generally, doses above 4 mg provide little additional effect, though some patients may benefit from increases up to 6 mg or 8 mg.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or coma. Those who have had allergic reactions to this medication or to sulfonylureas, or sulfonamides should not take it. There is no experience with use in patients with severely impaired liver or kidney function, and in such cases, switching to insulin therapy is recommended. Pregnant or breastfeeding women, or those who may become pregnant, should not take this medication. Patients with severe infections or those undergoing surgery, or who have severe trauma should also be switched to insulin therapy. When there are gastrointestinal disturbances like diarrhea or vomiting, food absorption may not be adequate which increases the risk of hypoglycemia, so caution is needed. This medication contains lactose and should not be taken by those with lactose intolerance or congenital disorders such as lactase deficiency or glucose-galactose malabsorption. During the initial week of treatment, the risk of hypoglycemia is heightened, so blood glucose should be monitored frequently and symptoms should be carefully observed. Poor nutritional status, irregular eating patterns, skipping meals, imbalances between exercise and carbohydrate intake, and frequent alcohol consumption can increase the risk of hypoglycemia. Caution is also needed in individuals with impaired kidney or liver function, the elderly, and those taking other medications as the risk of hypoglycemia may be increased. Symptoms of hypoglycemia may include headache, severe hunger, nausea, fatigue, drowsiness, confusion, dizziness, loss of consciousness, and if these symptoms occur, sugar should be ingested immediately. Visual disturbances, dyspepsia, liver dysfunction, hematological abnormalities, and allergic reactions may rarely occur, and if these symptoms arise, the patient should consult a doctor. While taking this medication, regular meals, exercise, and weight management should be implemented, and the condition of blood glucose control should be consistently monitored. In case of hypoglycemia, immediately consuming sugar or a sugary drink is the most effective solution. If undergoing treatment from another physician or pharmacist, it is essential to inform them of the intake of this medication and the state of diabetes. During stress situations like surgeries, infections, or trauma, blood glucose control may become difficult, thus temporary switching to insulin therapy may be necessary. This medication is eliminated through the kidneys, and older adults or those with decreased kidney function should be careful with dosage adjustments. In case of overdose, hypoglycemia may worsen, and prompt medical attention should be sought, even after hypoglycemia symptoms have ceased, for close observation for 1 to 2 days is necessary. When storing this medication, keep it out of the reach of children, and store it in the original container, tightly sealed. Finally, this medication may interact with other drugs, so if you are taking other medications, be sure to inform the healthcare provider.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blistering, peeling skin, pain in mouth/eye mucous membranes, breathing difficulties, asthma attacks, respiratory abnormalities with cough and fever, jaundice (yellowing of skin or eyes), generalized malaise, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, significantly reduced urine output, severe systemic reactions.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• reduced concentration
• decreased agility or activity

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. Additionally, it should be stored at room temperature that is not too cold or too hot, between 1°C to 30°C.

Appearance

Green rectangular tablets

Package unit

30 tablets/bottle, 100 tablets/bottle