Cofsim Dry Syrup 50mg/5mL (Cefpodoxime Proxetil)

Adult dose

○ Adults: Administer 100mg (potency) of cefpodoxime orally per dose, 2 times daily after meals. In severe cases or when the effect is considered insufficient, administer 200mg (potency) orally per dose, 2 times daily after meals. The dose may be adjusted according to age, symptoms, etc.

Child dose

○ Infants and children: Administer 3mg (potency) of cefpodoxime per kg of body weight orally per dose, 2～3 times daily, after reconstitution as a suspension before use. In severe cases or when the effect is considered insufficient, administer 4.5mg (potency) per kg of body weight orally per dose, 3 times daily. The dose may be adjusted according to age, symptoms, etc.

This medication contains the artificial sweetener aspartame, which is broken down into phenylalanine in the body. Therefore, it should not be used in patients with the genetic condition phenylketonuria. Since this medication contains lactose, it should not be administered to patients with genetic issues such as galactose intolerance, lactose deficiency, or glucose-galactose malabsorption. It is generally advised not to administer this medication to patients who have had allergic reactions to this drug or cephalosporin antibiotics. Careful consideration should be taken in patients who are allergic to penicillin or are prone to allergies, such as those with bronchial asthma or skin rashes. Patients with severely impaired kidney function need to be cautious as this medication is excreted through the kidneys, which can lead to higher drug concentrations. Patients who have difficulty taking medications orally, are receiving non-oral nutrition, are elderly, or in poor general health may experience vitamin K deficiency symptoms, thus their condition should be carefully monitored. This drug can rarely cause severe allergic reactions such as anaphylaxis; if symptoms like discomfort, oral irregular sensations, difficulty breathing, dizziness, or sweating occur, the medication should be stopped immediately. Also, if rashes, hives, itching, fever, or joint pain appear, the medication should be discontinued, and appropriate treatment should be sought. Digestive system issues may include severe colitis, diarrhea, nausea, vomiting, and abdominal pain, so any symptoms should be reported immediately. Respiratory symptoms may include fever, cough, and difficulty breathing; if such symptoms occur, the medication should be stopped and proper treatment sought. Blood tests may reveal decreased or increased platelets or white blood cells, so regular blood tests are recommended during extended use. This drug can affect the central nervous system, causing cognitive impairment or seizures in patients with reduced kidney function, so caution is advised. Severe skin reactions may occur; if skin rashes, blisters, or severe itching arise, the drug should be stopped immediately. Liver or kidney function abnormalities may appear, so regular monitoring is necessary. Long-term use may lead to phenomena like oral thrush or candida, so care must be taken. Symptoms of vitamin K and B deficiency may occur; thus, nutritional status should be managed carefully. This drug should only be used for the minimal time necessary to prevent resistance and checking allergic history is crucial before use. Caution is necessary when driving or operating machinery as dizziness may occur. Especially for those taking it for more than 10 days, checking white blood cell counts through blood tests is essential. Patients with reduced kidney function may require dose adjustment, and immediate reporting is necessary if abnormal symptoms occur. Use during pregnancy is not established for safety; therefore, it should only be used when the benefits outweigh the risks, and nursing mothers should discontinue breastfeeding. It is advisable not to use this drug in infants under 2 months of age, newborns, or premature babies, as safety has not been established. Elderly patients are more susceptible to adverse reactions due to reduced bodily functions and may face bleeding risks due to vitamin K deficiency, so dosages and intervals should be adjusted accordingly and observed closely. After compounding this drug, refrigerate and use it within two weeks, and shake well before taking. Caution is advised when used with other diuretics or aminoglycoside antibiotics, as there may be a risk of impaired kidney function. Also, concomitant use with drugs that alter gastric pH, such as antacids, may affect the drug's efficacy; consult with a physician or pharmacist.

Shock, anaphylactic reaction, malaise, oral dysesthesia, wheezing, dizziness, diarrhea, tinnitus, sweating, rash, urticaria, erythema, itching, fever, lymphadenopathy, arthralgia, pseudomembranous colitis, hematochezia, severe colitis, abdominal pain, frequent diarrhea, nausea, vomiting, diarrhea, loose stools, gastric pain, anorexia, abdominal discomfort, constipation, fever, cough, dyspnea, interstitial pneumonia, eosinophilic lung infiltration, eosinophilia, thrombocytopenia, thrombocytosis, leukopenia, neutropenia, cognitive dysfunction, behavioral disturbance, convulsion, seizure, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction (DRESS), acute generalized exanthematous pustulosis (AGEP), erythema multiforme, increased AST, increased ALT, increased ALP, increased LDH, elevated bilirubin, hematuria, elevated BUN, increased serum creatinine, acute renal failure, stomatitis, candidiasis, symptoms of vitamin K deficiency, hypoprothrombinemia, bleeding tendency, symptoms of vitamin B complex deficiency, glossitis, neuritis, headache, edema, sensory disturbances, fatigue, malaise

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and the storage temperature should remain within room temperature between 1 degree and 30 degrees Celsius. Therefore, when using the medication, always close the lid tightly, and avoid places that are too hot or too cold.

Appearance

Pale pink to pale purple granules

Package unit

200 milliliters/bottle