Remed Tablet 2mg (Glimepiride)

Adult dose

This medication is administered orally once daily. Start with a dosage of 1 mg of glimepiride once daily, increasing the dosage by 1 mg at intervals of 1-2 weeks as needed. Generally, there are minimal additional effects when doses exceed 4 mg, although some patients may increase to 6 mg or 8 mg. If 4 mg daily fails, consider switching to insulin therapy or using insulin or other oral medications.

This medication should not be used in patients with insulin-dependent diabetes or diabetic ketoacidosis, or those in a state of coma. Patients allergic to this medication, its components, or sulfonylureas should also not take it. It is not recommended for use in patients with severely impaired liver or kidney function as safety has not been established; in such cases, switching to insulin therapy is advised. Women who are pregnant or likely to become pregnant, as well as nursing mothers, should not take this medication. Patients with severe infections, or those undergoing surgery or experiencing severe trauma may require insulin therapy. Care should be taken when gastrointestinal issues such as diarrhea or vomiting are present, as food absorption may be compromised, increasing the risk of hypoglycemia. During the first week of taking the medication, there is a heightened risk of hypoglycemia, necessitating close monitoring of blood sugar levels. Special caution is required for the elderly, those with poor nutritional status, irregular eaters, or individuals whose exercise and food intake do not match. Those consuming alcohol or with impaired kidney or liver function may also respond sensitively to hypoglycemia, so careful intake is necessary. Furthermore, overdosage or abnormalities in thyroid, pituitary, or adrenal function can increase the risk of hypoglycemia. When taking this medication alongside others, potential interactions may occur, thus it is imperative to inform your doctor or pharmacist for proper management. This medication has a blood sugar-lowering effect, which could lead to symptoms of hypoglycemia. Symptoms include headache, severe hunger, nausea, fatigue, drowsiness, anxiety, confusion, visual disturbances, dizziness, weakness, and in severe cases, loss of consciousness or coma. Severe hypoglycemia can present symptoms similar to a stroke, thus immediate treatment is required. Additionally, blurred vision may occur initially, along with gastrointestinal symptoms such as nausea, vomiting, abdominal pain, or diarrhea. Serious side effects such as liver dysfunction or decreased blood cell counts may also occur rarely, so any abnormal symptoms should be reported to a healthcare professional immediately. When taking this medication, it is essential to take it regularly in conjunction with dietary and exercise therapy for optimal blood sugar control. In case of hypoglycemia, it is important to consume sugar or sugary beverages quickly, and it is advisable to always carry sugar. Education on hypoglycemic symptoms and their management should be thoroughly provided to patients and their families. Regular blood sugar and urine tests should be performed during treatment to monitor the drug's efficacy and side effects, and dosage adjustments should be discussed with a doctor if conditions change. Furthermore, caution should be exercised during driving or operating machinery to avoid accidents due to hypoglycemia. As this medication is metabolized in the liver, its interaction with specific drugs may affect blood sugar control. Notably, some antibiotics, antifungals, antihypertensives, and anticoagulants may interact, hence it is crucial to inform healthcare providers about other medications being taken. Alcohol intake can unpredictably affect blood sugar control, necessitating caution, and adjusting the timing of medication intake is also important. Pregnant or breastfeeding women should avoid this medication as it may harm the fetus or newborn. In cases of planned pregnancy, consulting with a doctor to choose alternative methods like insulin therapy is advisable. The safety of this medication has not been adequately established in children and adolescents under 18 years, and therefore, it should not be used as a principle. For the elderly, careful attention is needed due to potentially diminished kidney function, including dosage adjustments. In the event of overdose, severe hypoglycemia may occur, necessitating immediate emergency treatment. Induction of vomiting, gastric lavage, or glucose injection may be required. This medication should be stored in a safe place out of the reach of children, in its original container to prevent misuse or degradation of quality.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, shortness of breath, cold sweats, pallor → severe allergic reactions. Severe rash accompanied by high fever, blistering, peeling skin, pain in the oral/evidence of inflammation of the mucous membranes of eyes → severe skin adverse reactions. Jaundice (yellowing of the skin or eyes), hepatic dysfunction. Loss of consciousness and coma due to severe hypoglycemia, convulsions. Thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or motivation

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is best stored at room temperature between 1°C and 30°C. This will help maintain its efficacy for a longer duration.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 300 tablets/bottle