Famciclovir 250 mg Tablet

Adult dose

1. Treatment of herpes zoster Adults: Administer 250 mg of famciclovir per dose orally 3 times daily for 7 days. It is advisable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this medicine per dose orally 3 times daily for 5 days. It is advisable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this medicine per dose orally twice daily for 5 days. It is advisable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine per dose orally twice daily. Periodically discontinue treatment every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 : 250 mg per dose twice daily 10～29 : 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 : 125 mg per dose twice daily 10～29 : 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 : 250 mg per dose twice daily 10～29 : 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, it is advisable to administer this medicine every 48 hours, taking the dialysis interval into account. A 4-hour hemodialysis session reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medicine should not be used by patients who are allergic to this medication or its components, or to the active ingredient, penciclovir. Additionally, this medication contains lactose, so individuals with genetic problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take it. Patients with impaired kidney function should use this medication with caution and may require dose adjustments as needed. Some patients may experience side effects such as headache, dizziness, nausea, vomiting, skin rash, itching, and liver function abnormalities, so caution is advised. Particularly, elderly patients may experience symptoms such as drowsiness or confusion more frequently, and it is advisable to avoid driving or operating machinery if these symptoms occur. This medication does not completely cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual practices if symptoms are present during treatment. Women who are pregnant or breastfeeding should consult a doctor before taking this medication and should only use it when the benefits outweigh the risks. The safety and efficacy of this medication have not been established in children under 18 years of age, so it is advisable not to use it. This medication has a low likelihood of drug interactions, but it is important to inform healthcare providers of all medications being taken, as certain medications may affect its efficacy or side effects. In case of overdose, proper treatment is necessary, and hemodialysis can be used to reduce the concentration of the active ingredient in the blood. When storing, it should be kept in a dry place below 30 degrees Celsius, out of reach of children, and it should not be transferred to other containers.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication should be stored in a tightly closed container to prevent air and moisture from entering and kept in a cool, dry place below 30 degrees Celsius. Proper storage helps maintain the medication's efficacy for a longer period.

Appearance

White to off-white oval film-coated tablet

Package unit

21 tablets/bottle