Painclear Tablets

Adult dose

Children aged 12 and older and adults: The dosage should be adjusted according to the degree of pain and therapeutic response. A loading dose of 4 tablets is recommended, and subsequent doses should be at least 6 hours apart but not exceeding 16 tablets per day. Administer the lowest effective dose for the shortest duration possible. Avoid prolonged use beyond necessary, and if long-term use is needed due to the characteristics and severity of the disease, conduct regular monitoring to assess the continued use of this medication. Elderly Administer the usual adult dosage. However, in patients over 75 years, the elimination half-life of tramadol increased by 17% upon oral administration, so dosing should be spaced at least 6 hours apart. Renal Impairment For moderate renal impairment patients (creatinine clearance 10-30ml/min), extend the dosing interval to 12 hours. For severe renal impairment patients (creatinine clearance below 10ml/min), this medication is not recommended. Tramadol is eliminated very slowly by hemodialysis and filtration, so there is no need to readminister this medicine after dialysis for pain relief maintenance. Hepatic Impairment For moderate hepatic impairment patients, careful consideration should be given to extend the dosing interval. This medication should not be administered to patients with severe hepatic impairment.

Child dose

Children aged 12 and older and adults: The dosage should be adjusted according to the degree of pain and therapeutic response. A loading dose of 4 tablets is recommended, and subsequent doses should be at least 6 hours apart, but not exceeding daily.

This medication may burden the liver, so those who consume more than three alcoholic drinks daily must consult a physician or pharmacist before use. If any abnormal reactions such as skin rash or itching occur while taking this medication, discontinue use immediately and consult a healthcare provider. Due to the risk of seizures, patients with a history of seizures or risk factors for seizures should use this medication with caution, and the risk of seizures may increase when combined with certain antidepressants or opioid analgesics. This drug can rarely cause serious allergic reactions; if symptoms such as difficulty breathing or hives occur, immediate medical treatment is necessary. Patients with acute and severe asthma are at risk of respiratory suppression when taking this medication, so it should only be used in a properly equipped environment. Taking this medication with alcohol or benzodiazepines can lead to severe drowsiness or respiratory suppression, so concurrent use should be avoided or done with extreme caution. Patients with head injuries or brain diseases should be cautious, as this medication can increase intracranial pressure. This drug can lead to physical and psychological dependence, so prolonged use should only occur under a doctor’s guidance. Patients with impaired liver function must consult a physician before taking this medication, as it contains acetaminophen which poses a risk of liver damage. Patients with certain genetic profiles may metabolize this drug rapidly, increasing the risk of respiratory suppression; such patients require special medical management. This medication should not be administered to children under 12 years or to adolescents under 18 years following certain surgeries. Patients with sleep apnea should be closely monitored, as symptoms may worsen while using this medication. Electrolyte imbalances such as hyponatremia may occur, so elderly patients or those with risk factors should undergo blood testing to assess their condition. Patients with hypersensitivity to this medication or those prohibited from taking certain drugs should not take this product. Patients in a state of severe respiratory suppression, those with head injuries, or those taking MAO inhibitors should not use this medication. This drug may cause drowsiness or dizziness, so caution is needed during driving or the operation of hazardous machinery. In cases of overdose, serious respiratory suppression, seizures, or liver damage may occur, so prescribed dosages must be strictly followed, and immediate emergency treatment is necessary in case of overdose. This medication can interact with various drugs, so inform healthcare providers of any other medications being taken. Pregnant or breastfeeding women should consult a physician before using this medication, as it may affect the fetus or newborn. This medication must be kept out of reach of children and managed carefully to prevent drug misuse.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in the mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough + fever, yellowing of skin or eyes (jaundice), extreme drowsiness, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

This product should be stored in a tightly sealed container to prevent air and moisture from entering. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Light yellow rectangular film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle