Exolazol 20 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

Swallow with a liquid such as water; do not chew or crush. Treatment of erosive reflux esophagitis: Take 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take it for an additional 4 weeks. Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Once symptoms have subsided, control subsequent symptoms by taking 20 mg once daily. Adults may take 20 mg once daily as needed. For patients at high risk of developing gastric and duodenal ulcers due to nonsteroidal anti-inflammatory drug use, as-needed administration is not recommended for controlling recurring symptoms. Administer this medicine 20 mg with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days. 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Clinical trials lasting longer than 4 weeks have not been conducted. Treatment of gastric ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. The treatment period is 4∼8 weeks. Prevention of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. The recommended initial dose is 40 mg twice daily. The dose should then be adjusted for each patient, and treatment should continue while clinical symptoms are present. Clinical data indicate that most patients can be controlled with doses of 80 ∼ 160 mg per day. Doses exceeding 80 mg per day should be divided into 2 doses. Administer 40 mg once daily for 4 weeks following induction of prevention of rebleeding due to gastric or duodenal ulcers with intravenous administration. Renal impairment: No dose adjustment is necessary. Use with caution because there is limited experience with administration to patients with severe renal failure. Hepatic impairment: No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dose of this medicine should not exceed 20 mg. Elderly patients: No dose adjustment is necessary.

Children's dosage

Adolescents 12 years of age and older — Treatment of erosive reflux esophagitis: Take 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take it for an additional 4 weeks. Adolescents 12 years of age and older — Symptomatic treatment of gastroesophageal reflux disease without esophagitis: 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Adolescents 12 years of age and older — Once symptoms have subsided, control subsequent symptoms by taking 20 mg once daily. Children under 12 years of age: There is no experience with administration of this medicine to children under 12 years of age.

This drug should not be used in patients with allergic reactions or hypersensitivity to certain components, particularly those who are hypersensitive to benzimidazole derivatives, penicillin antibiotics, or macrolide antibiotics. Additionally, caution is needed for those receiving certain cardiovascular drugs, patients with a history of myocardial infarction, and nursing women, who should preferably avoid this medication. This medication contains the dye Yellow No. 4, and patients allergic to this ingredient should use it with caution. Various adverse reactions may occur during treatment, including headache, abdominal pain, diarrhea, skin rash, muscle pain, etc. Rarely, serious blood abnormalities or liver dysfunction may occur, so if symptoms appear, consult a doctor immediately. For long-term use, regular health check-ups are necessary, especially for magnesium levels and bone density, as the risk of hypomagnesemia or fractures may increase. Also, this drug suppresses gastric acid secretion which can lead to bacterial overgrowth in the stomach; if diarrhea or infection symptoms persist, notify healthcare professionals. It has many drug interactions, especially when taken in conjunction with antiviral medicines, anticoagulants, antibiotics, and anticonvulsants; follow expert guidance. Safety during pregnancy has not been fully established, so caution is warranted, and it is recommended not to use this drug during breastfeeding. In case of overdose, there is no specific antidote, so visit a medical institution immediately for appropriate treatment and keep it out of the reach of children.

Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, fever, angioedema, anaphylaxis, shock, peripheral edema, hyponatremia, hypomagnesemia, insomnia, anxiety, confusion, depression, aggression, hallucinations, headache, dizziness, paresthesia, drowsiness, dysgeusia, blurred vision, bronchospasm, pancreatitis, abdominal pain, constipation, diarrhea, abdominal distension, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, increased liver enzymes, hepatitis, liver failure, encephalopathy, dermatitis, itching, rash, urticaria, alopecia, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized pustular exanthema, drug reactions associated with eosinophilia and systemic symptoms, fractures, arthralgia, myalgia, muscle weakness, interstitial nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal bloating, allergic reactions, back pain, chest pain, substernal pain, facial edema, facial flushing, fatigue, fever, influenza-like illness, generalized edema, leg swelling, malaise, pain, rigidity, peripheral edema, flushing, hypertension, tachycardia, thyroid mass, irritable bowel syndrome, exacerbation of constipation, dyspepsia, dysphagia, gastrointestinal malformation, upper abdominal pain, belching, esophageal disorders, frequent bowel movements, gastroenteritis, gastrointestinal bleeding, hiccups, melena, oral disorders, pharyngeal disorders, rectal disorders, gastrointestinal symptoms, increased serum gastrin, tongue disorders, tongue swelling, ulcerative stomatitis, earache, tinnitus, anemia, hypochromic anemia, cervical lymphadenopathy, epistaxis, leukocytosis, leukopenia, thrombocytopenia, hyperbilirubinemia, liver dysfunction, elevated ALT, elevated AST, diabetes, hyperuricemia, elevated ALP, thirst, vitamin B12 deficiency, weight gain, weight loss, exacerbation of arthritis, arthropathy, seizures, fibromyalgia syndrome, hernia, rheumatoid polymyositis, decreased appetite, apathy, increased appetite, confusion, exacerbation of depression, hypertonia, sensory loss, erectile dysfunction, insomnia, migraine, exacerbation of migraine, sleep disorders, tremors, visual field defects, dysmenorrhea, menstrual disorders, vaginitis, exacerbation of asthma, cough, dyspnea, laryngeal edema, pharyngitis, rhinitis, sinusitis, acne, anal itching, erythematous rash, papular rash, otitis media, altered olfaction, loss of taste, taste distortion, abnormal urination, albuminuria, cystitis, dysuria, fungal infection, hematuria, urination frequency, candidiasis, genital candidiasis, polyuria, conjunctivitis, visual disturbances, duodenitis, esophagitis, esophageal stricture, esophageal ulcer, esophageal varices, gastric ulcer, gastritis, benign polyp or nodule, Barrett's esophagus, mucosal pigmentation, hernia, systemic lupus erythematosus, discoid lupus erythematosus, hypocalcemia, hypokalemia, rhabdomyolysis

This medication should be stored in a sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature to preserve the drug's effectiveness and safety.

Appearance

Light pink round film-coated tablet

Package unit

28 tablets/PTP (Alu-Alu)