MPM Injection 1 Gram (Meropenem Trihydrate)

Adult administration

For meropenem, administer 0.5 to 1 g per day (potency) divided into 2 to 3 doses via slow intravenous infusion for more than 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, neutropenia, or sepsis, administer 1 g (potency) via slow intravenous infusion every 8 hours. For cystic fibrosis and meningitis, administer 2 g (potency) via slow intravenous infusion every 8 hours.

Child administration

For bacterial meningitis in children older than 3 months, administer 40 mg per kg of body weight every 8 hours via slow intravenous infusion for more than 30 minutes, based on the pathogen's susceptibility and the patient's condition.

This medication should not be administered to certain patients. For example, patients who have previously experienced severe shock reactions to this drug or are taking sodium valproate should not use this medicine. Additionally, patients who have previously had allergic reactions to this drug or its components, or who have shown severe allergic reactions to other carbapenems or beta-lactam antibiotics, should also not receive this medication. Patients with impaired kidney function, epilepsy, or central nervous system disorders should use this drug cautiously, as it may remain in the body for a prolonged period, potentially leading to neurological symptoms such as seizures or altered consciousness. Patients with severely impaired liver function, elderly patients, and those with poor nutritional status or infants under 3 months should also be administered this drug carefully. While using this medication, rare allergic reactions such as shock, anaphylaxis, rash, and urticaria may occur, so patients’ conditions should be monitored closely. Blood tests may show abnormalities such as reduced blood cell counts, anemia, liver dysfunction, or kidney impairment, requiring regular testing. Moreover, if severe diarrhea or abdominal pain occurs, administration should be stopped immediately, and appropriate treatment should be initiated. To prevent the development of resistant bacteria, it is important to only administer this drug for the minimum necessary duration. Prior to administration, it is recommended to check for bacterial susceptibility, and during treatment, susceptibility should be re-evaluated on the third day to determine if appropriate therapy is being carried out. Since there is a potential for shock, a patient’s history of allergies and skin reactions should be reviewed before administration, and patients should be monitored closely after administration to ensure stability. This medication may interact with other drugs, so caution is required, especially when used in combination with probenecid, valproate, antiepileptic drugs, and hormonal contraceptives. Women who are pregnant or may become pregnant should carefully weigh the risks and benefits of using this drug, and it is advisable to avoid administration during breastfeeding. Elderly patients may experience side effects more frequently when using this drug and may have an increased risk of bleeding due to vitamin K deficiency, necessitating careful monitoring. This drug is for intravenous use only, and should be used promptly following preparation; if storage is necessary, it should be used within a specified timeframe.

Serious side effects

Shock, anaphylaxis, urticaria, angioedema, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, DRESS syndrome, erythema multiforme, acute generalized exanthematous pustulosis), jaundice, liver failure, acute renal failure, severe colitis, seizures, altered consciousness, asthma, shortness of breath, interstitial pneumonia, pulmonary edema, PIE syndrome, fulminant hepatitis

Mild side effects

• Oral abnormal sensation
• wheezing
• dizziness
• tinnitus
• sweating
• rash
• warmth sensation
• erythema
• itching
• fever

This drug should be stored in a sealed container to prevent exposure to air, and it is important to maintain a storage temperature between 1 degree and 30 degrees Celsius. This ensures that the drug's effectiveness is preserved and it can be used safely.

Appearance

Vial filled with crystalline powder, white to pale yellow in color

Package unit

10 vials