Roxithromycin Tablets (Roxithromycin)

Adult dose

Adults: Administer roxithromycin 150㎎ (potency) orally per dose, 2 times daily before breakfast and dinner. For pneumonia, administer 300mg (potency) once daily before breakfast. The dose may be adjusted according to age and symptoms.

This drug can rarely cause serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, so if symptoms such as blistering of the skin or mucous membrane damage occur, use should be discontinued immediately. Patients with a history of allergy to this drug or hypersensitivity to macrolide antibiotics should not use it. Additionally, patients taking certain drugs such as terfenadine, astemizole, cisapride, pimocodeine, ergot alkaloids, or mizolastine should not use this drug. Caution should be exercised when using this drug in patients with poor liver function or the elderly, and care must be taken when used in conjunction with other antibiotics due to potential drug interactions and impacts on cardiac electrical signals. Particularly, patients with heart disease or those taking specific antiarrhythmic drugs should be careful of the risks of heart-related side effects. This drug can rarely cause shock due to allergic reactions, so any unusual symptoms should be reported to healthcare personnel immediately. Furthermore, various side effects such as hepatitis, gastrointestinal issues, diarrhea, pneumonia, neurological symptoms, taste and smell abnormalities, and hearing problems may occur, hence symptoms should be closely monitored. Long-term use of this drug can lead to the development of resistant bacteria, so it is advisable to use it only for the necessary minimum duration following susceptibility testing of the infecting organisms. Patients with impaired liver function should undergo regular liver function tests and adjust dosing accordingly; however, patients with decreased kidney function do not require separate dose adjustments. In children, excessive dosing should be avoided, and the prescribed dosage and duration should be strictly adhered to. This drug may interact with other medications, so especially when taken with certain antihistamines, antiarrhythmics, theophylline, warfarin, cyclosporine, midazolam, or digoxin, consultation with healthcare personnel is required. Pregnant women or those with the possibility of pregnancy should carefully consider the potential impact on the fetus before using this drug, weighing the benefits and risks; nursing mothers should avoid use if possible and discontinue breastfeeding if this drug must be used. The elderly may experience a prolonged half-life of this drug, but generally, dose adjustments are not necessary. This drug may cause dizziness or blurred vision, so caution should be taken when operating machinery or driving. Lastly, this drug should be stored out of reach of children and not transferred to other containers for safety and quality maintenance.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, anaphylactic shock, fever, rash, allergic skin reactions, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatocellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, increased serum bilirubin, loss of appetite, nausea, vomiting, discomfort in the stomach, abdominal pain, abdominal distension, diarrhea, membranous colitis, loose stools, hemorrhagic colitis, blood in stool, pancreatitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue numbness, paralysis, taste disturbance, ageusia, smell disturbance, anosmia, erythema multiforme, purpura, superinfection with non-susceptible pathogens, transient hearing loss, auditory impairment, visual disturbances, blurred vision, conjunctival injection, generalized malaise, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, nasal bleeding, menstrual irregularities, inflammation of oral and vaginal mucosa, hallucinations, confusion

This drug should be stored in a tightly sealed container to prevent air exposure, ideally at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the drug's efficacy and prevent degradation.

Appearance

White, round, biconvex tablet

Package unit

30 tablets/bottle, 300 tablets/bottle