Ogutin 625 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

Adults and children aged 12 years or older or weighing 40 kg or more receive 250 mg/125 mg of amoxicillin/clavulanate potassium orally three times a day every 8 hours. In cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg. In patients with renal impairment, dosage may be adjusted according to creatinine clearance.

Child dose

Children aged 12 years or older or weighing 40 kg or more follow the same dosage as adults. Those with renal impairment should also have their dosage adjusted in the same manner.

This drug is a beta-lactam antibiotic and should not be administered to patients with hypersensitivity to penicillins and cephalosporins. Caution is particularly necessary for patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with a history of liver dysfunction or jaundice should avoid using this medication as symptoms may recur. Patients with liver impairment or moderate to severe renal impairment may experience elevated drug concentration, and dosing should be done carefully. Patients with allergic constitution or frequent manifestations such as bronchial asthma or skin rashes should be cautious when taking this medication. Additionally, patients with gastrointestinal diseases like vomiting or diarrhea may have impaired drug absorption. This medication may cause gastrointestinal side effects such as diarrhea, vomiting, and abdominal pain, and in severe cases, pseudomembranous colitis may occur, requiring immediate consultation with a physician upon symptom occurrence. Symptoms of abnormal liver function have also been reported, and regular liver function tests should be conducted during prolonged use. Rarely, severe side effects such as skin rashes, anaphylaxis, blood abnormalities, and renal dysfunction may manifest, and immediate discontinuation and reporting to medical personnel are necessary if unusual symptoms appear. This medication can interact with other drugs, so it is essential to inform healthcare providers of any concurrent medications, especially when combined with anticoagulants or specific antibiotics. The use of this medication is limited in pregnant or breastfeeding women and should only be administered after sufficient consultation with a physician if necessary. Experience with pediatric use, particularly in children under 12 years of age or weighing less than 40 kg, is limited and therefore not recommended. Elderly patients may have an increased risk of side effects due to declining renal and liver function, requiring careful adjustment of dosage and administration intervals with close monitoring. In cases of overdose, gastrointestinal symptoms, renal impairment, and neurological abnormalities may occur; hence immediate medical attention for appropriate treatment is required. This medication should be stored in a closed container in a dry place below 25 degrees Celsius. Prolonged use may lead to the development of resistant bacteria and an increased risk of side effects; hence it should only be used for the minimal period as directed by a physician.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rashes, blisters, skin peeling, pain in the mouth/eyes mucosa, severe skin reactions, asthma attacks, respiratory issues accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme fatigue, liver abnormalities (jaundice), sudden and severe headaches, lightning-like headaches, seizures

Mild side effects

Diarrhea, pseudomembranous colitis, indigestion, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal bloating, constipation, colonic pain, gastric acidity, loose stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-associated colitis, blood in stool, elevated AST, ALT, ALP, LDH, serum bilirubin, hepatitis, itching, erythema multiforme, angioedema, serum sickness, hypersensitivity vasculitis, acute generalized exanthematous pustulosis, bronchospasm

This medication should be kept in a sealed container to avoid moisture and stored in a dry place below 25 degrees Celsius. Proper storage will help maintain the medication's efficacy for a longer time.

Appearance

White or almost white rectangular film-coated tablet

Package unit

60 tablets (4 tablets/PTP × 15)