Mavid Tablet 500mg (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) per dose twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer this drug 500mg (potency) 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, individuals allergic to the additives in this medication or to macrolide antibiotics should not take it, nor should patients with severe heart disease, liver impairment, or kidney disease. Additionally, pregnant or breastfeeding women should avoid this medication; caution is also required for patients taking certain specific medications as they may pose risks when used concurrently with this drug. Patients with impaired liver or kidney function, those with heart disease, and elderly patients should exercise greater caution when using this medication, especially if used alongside other antibiotics due to potential interactions. Rarely, this medication may cause severe allergic reactions, skin rashes, liver dysfunction, kidney dysfunction, gastrointestinal disorders, central nervous system symptoms, etc. Therefore, if any unusual symptoms occur while taking this medication, it is imperative to consult a physician immediately. This medication can interact with other drugs; particularly, those affecting heart medications, liver metabolism, blood glucose-lowering medications, anticoagulants, and certain antiviral drugs should be discussed with a professional prior to concurrent use. Pregnant or lactating women are advised against taking this medication; if it must be taken, breastfeeding should be discontinued. Children and the elderly should have their dosages carefully adjusted or evaluated before use; especially elderly patients with reduced kidney function may require dosage adjustments. Long-term or excessive use of this medication may result in adverse effects such as auditory disturbances, tinnitus, hypoglycemia, thus it is crucial to adhere to the prescribed dosage guidelines. If symptoms such as diarrhea, abdominal pain, rash, or difficulty breathing occur during use, the medication should be discontinued, and medical attention should be sought immediately as there may be risks associated with serious intestinal conditions such as pseudomembranous colitis. This medication may necessitate caution when driving or operating machinery; if dizziness or confusion occurs after taking it, one should avoid driving or engaging in hazardous activities. To use this medication safely, it is vital to take it according to the physician's prescription and guidance, and always consult a healthcare professional when using other medications.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, convulsive form, dryness of mouth, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrate, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug eruption accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, hepatic failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, elevated total bilirubin, loss of appetite, dark-colored urine, pruritus, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, malaise, elevated CPK, increased serum myoglobin, increased urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste distortion, hearing loss, dysesthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, rhabdomyolysis, purpuric rash, acute generalized exanthematous pustulosis, muscle cramps, musculoskeletal rigidity, myopathy, elevated serum creatinine, elevated blood urea, renal failure, nephritis, venous inflammation at the injection site, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color, mental status changes, obsessive behavior, hypokalemia, hypoxemia

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. Additionally, to maintain the effectiveness of the drug, it should be kept in a dry place away from light. The ideal storage temperature is between 15 and 30 degrees Celsius.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/bottle