Clarithromycin Tablet 250mg (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to such patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years or older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This medication should not be used by patients who have allergies to certain additives. Additionally, patients with a history of allergies to similar classes of antibiotics should avoid this medication. Co-administration with certain heart-related medications may result in cardiac rhythm abnormalities and should be avoided. This medication should not be used or should be used very cautiously in patients with severe heart disease or liver function impairment. Patients with severely compromised kidney function also need to be cautious while using this medication. It is safer for pregnant or breastfeeding women not to take this medication. Patients with central nervous system infections or those taking certain other medications should consult a specialist before administering this medication. This medication contains lactose, so patients with lactose intolerance should not take it. Patients with weak liver or kidney function may require dose adjustment. Long-term use of this medication may lead to resistant bacteria, so it is important to use it for only the necessary duration. During administration, watch closely for allergic reactions, gastrointestinal disturbances, liver function anomalies, and other side effects. If cardiac rhythm abnormalities, hepatitis, kidney function decline, or severe allergic reactions occur, discontinue use immediately and consult a healthcare provider. Many drug interactions exist, so inform healthcare providers about any medications being taken. Caution is required while driving or operating machinery due to possible dizziness or confusion. Overdose may lead to gastrointestinal disturbances or central nervous system abnormalities, and immediate emergency treatment is necessary.

Shock, anaphylactic symptoms, shortness of breath, seizures, erythema, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, altered taste, anorexia, constipation, stool discoloration, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory impairment, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular dermatitis, muscle spasms, musculoskeletal stiffness, myopathy, elevated blood urea, venous thrombophlebitis at injection site, pain at injection site, inflammation at injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light and should be stored in a light-protected container. Additionally, it should be stored at room temperature between 15 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle