Claton Tablet (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7~14 days. For patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) 3 times daily for 14 days together with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. In other words, administer clarithromycin 500mg (potency) per dose, 3 times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).

Child dose

○ Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be taken by individuals who are hypersensitive to additives or macrolide antibiotics. In particular, it should not be administered to those with certain heart conditions or severely impaired liver and kidney function. Caution is required for those taking certain medications as this drug may cause issues with heart rhythm. It is safest for pregnant or breastfeeding women to avoid this medication. It is also advisable not to administer it to patients with central nervous system infections. Those with mild liver or kidney impairment may require dosage adjustments or careful monitoring. The elderly or individuals on other antibiotics should also use it cautiously. Various side effects such as allergic reactions, gastrointestinal disturbances, liver dysfunction, skin rashes, central nervous system symptoms may occur, so any abnormal symptoms should lead to immediate cessation of use and consultation with a doctor. To prevent the occurrence of resistant bacteria, it is important to use this medication for the necessary duration only, as long-term use might lead to resistance. If other medications are being taken, healthcare providers must be informed due to numerous drug interactions, and it is contraindicated with some drugs. In particular, the risk of side effects may increase when used with antidiabetic agents, anticoagulants, or heart-related drugs due to changes in blood concentration. Individuals with pregnancy potential or those breastfeeding should avoid taking this drug, and if unavoidable, breastfeeding should be discontinued. The safety for children is limited, thus it is recommended not to use it in children under 12 years of age. Elderly patients should be cautious due to the possibility of higher drug concentrations from reduced kidney function. Overdosage may cause gastrointestinal disturbances or central nervous system symptoms, requiring immediate medical attention. This drug should be stored at room temperature without refrigeration and kept away from direct sunlight.

Shock, anaphylactic symptoms, respiratory distress, seizures, flushing, rash, itching, hives, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distention, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal ulceration, upper abdominal pain, thirst, transient teeth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, membrane colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, orientation disturbance, hallucinations, psychosis, depersonalization, tremor, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, elevated total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste disorders, reversible hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpura-like rash, acute generalized exanthematous pustulosis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactoid reaction, angioedema, decreased appetite, anxiety, neural irritability, noise sensitivity, altered mental status, abnormal dreams, mania, movement disorders, non-vestibular dizziness, drowsiness, tremors, vestibular dizziness, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyltransferase, vesicular dermatitis, sweating, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myopathy, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental dosing, compulsive behavior, hypokalemia, hypoxemia

This medication may be sensitive to air and moisture; therefore, it should be stored in a tightly closed container. Additionally, it is crucial to store it in a dry place avoiding direct sunlight. The storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle