Kegrel Tablet (Clopidogrel Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, clopidogrel is administered orally once daily at a dose of 75 mg. 2. Patients with acute coronary syndrome start on day one with a loading dose of 300 mg orally once daily and continue with a maintenance dose of 75 mg orally once daily. At this time, aspirin 75-325 mg should be co-administered once daily. 3. Patients with atrial fibrillation...

This drug prevents blood clotting to prevent thrombus formation. Since this drug must be converted to its active form in the liver to be effective, individuals with genetically reduced function of the liver enzyme CYP2C19 may experience decreased efficacy. Therefore, in such cases, it is advised to change the treatment method or use other medications. Additionally, co-administration with drugs that activate CYP2C19 may increase the active metabolite concentration of this drug, raising the risk of bleeding, so concomitant use should be avoided. This drug should not be used in certain patients. For example, individuals allergic to this drug or its components, those with bleeding, individuals with severely impaired liver function, nursing mothers, and those with genetic issues such as lactose intolerance should not take this medication. Caution should be exercised when this drug is used in patients at high risk of bleeding. Especially if bleeding symptoms are suspected, a blood test should be performed immediately, and concurrent use with anticoagulants like warfarin may further increase the risk of bleeding, so care is needed. Patients scheduled for surgery should discontinue this drug 5 to 7 days before the procedure and can resume after hemostasis. During the administration of this drug, attention should always be paid to bleeding symptoms, and greater caution is advised when taken with other medications that pose a bleeding risk. The use of aspirin concomitantly may increase the risk of bleeding, so the necessity and risks of such combinations should be carefully considered. This drug may cause various side effects such as bleeding, decreased blood cell count, gastrointestinal disturbances, and skin rashes. In particular, bleeding may present as serious forms such as gastrointestinal bleeding and intracranial hemorrhage, so if bleeding symptoms occur, immediate notification to healthcare personnel is required. The fetal risk during pregnancy has not been confirmed, but given the risk of bleeding during delivery, it is advisable to discontinue use 5 to 7 days before delivery. While nursing, this drug may be excreted in breast milk, so discussions with a physician regarding whether to continue breastfeeding or discontinue medication are warranted. The safety and efficacy in pediatric patients have not been established, so it is better not to use this drug in children. Elderly patients are at increased risk of bleeding due to decreased renal and liver function, so careful monitoring of the patient's condition is necessary during administration. Overdosage may cause prolonged bleeding times and complications related to bleeding, and as there is no specific antidote, treatment may involve platelet transfusion if necessary. This drug should be stored out of reach of children, and care should be taken as transferring it to another container may compromise its quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, mucosal pain in the mouth/eyes, breathing difficulties or shortness of breath, asthma attacks, respiratory distress with cough and fever, jaundice (yellowing of the skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• edema
• hypertension
• headache
• dizziness
• abdominal pain

This drug should be stored in a tightly sealed container to prevent exposure to air and moisture and should be kept at room temperature between 1 and 30 degrees Celsius. Storing it this way can maintain the drug's effectiveness and prevent deterioration.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle