Pyrosin Tablets 500 Milligrams (Clarithromycin)

Adult dosage

○ Adults: The usual dose is 250mg (potency) of clarithromycin twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and creatinine clearance ≤30mL/min, reduce the dose by half. That is, administer 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28). ○ Children aged 12 years or older: Same as adults

Children's dosage

For children younger than 12 years, use clarithromycin dry syrup.

This medication should not be administered to patients who have hypersensitivity to any of its additives or active ingredients. Particularly, individuals allergic to certain classes of antibiotics may face risks when using this drug. Moreover, patients currently taking medications that affect heart rhythm should not combine this drug as it may lead to serious side effects such as arrhythmia. Use is restricted in patients with significantly impaired liver or kidney function, and it is safe for pregnant or breastfeeding women not to take this medication. Caution is also advised for patients with central nervous system infections or those on certain medications. Patients with compromised liver or kidney function, heart diseases, and the elderly should use this medication more cautiously, especially if taking it in combination with other antibiotics. This medication may rarely cause various side effects, including allergic reactions, gastrointestinal disturbances, neurological symptoms, skin rashes, and liver dysfunction; thus, immediate consultation with a healthcare professional is required if adverse effects occur. Furthermore, this medication has numerous interactions with other drugs; it is essential to inform healthcare professionals if taking other medications, especially those for heart diseases, anticoagulants, certain sedatives, and diabetes medications. The use of this drug is not recommended during pregnancy or breastfeeding unless discussed thoroughly with a healthcare professional. Special care is needed when dosing pediatric patients and the elderly. Overdose may lead to gastrointestinal discomfort or neurological symptoms, and immediate medical attention should be sought. Regular blood tests and assessments of liver and kidney function may be needed during treatment, and if abnormalities are observed, treatment should be discontinued promptly for appropriate management. Finally, as this medication may be sensitive to light and moisture, it should be stored in a sealed container away from direct sunlight and in a dry place.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, pruritus, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, dry mouth, transient teeth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, stool discoloration, membranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsion, tremor, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, stomatitis, glossitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle spasms, musculoskeletal stiffness, myopathy, elevated blood urea nitrogen, injection site thrombophlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased International Normalized Ratio, prolonged prothrombin time, abnormal urine color, cardiac arrest, atrial fibrillation, QT interval prolongation on ECG, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration

This medication should be stored in a sealed container that protects it from air and moisture. It is important to avoid direct sunlight and store it in a cool, dry place. The optimal storage temperature is between 15 degrees and 30 degrees.

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle