Metmin Tablet 500 mg (Metformin Hydrochloride)

Adult dose

The dosage should be determined based on individual drug effects and tolerance and should not exceed the recommended maximum daily dose. Start at a low dose and take 500 mg with meals 2 to 3 times a day. Increase the dosage gradually by 500 mg each week; for doses up to 2000 mg, take it divided into 2 doses in the morning and evening. If exceeding 2000 mg, it should be taken in 3 doses with meals.

Child dose

Children over the age of 10 and growing adolescents should take 500 mg once daily during or after meals. Blood sugar levels should be measured after one week to adjust the dosage, with a maximum daily dose of 2000 mg.

This medication can cause severe lactic acidosis or hypoglycemia, so caution should be exercised before taking it. Patients with moderate to severe kidney dysfunction, acute infections, or dehydration should avoid taking this medication. Patients with acute heart failure or myocardial infarction, as well as those undergoing examinations using iodinated contrast agents, should not use this medication. Those with hypersensitivity to this drug or with Type 1 diabetes or diabetic ketoacidosis should also refrain from using it. Patients with severe infections or trauma should stop taking this medication until the oral intake is recovered and kidney function is normal. Patients scheduled for surgery should stop this medication 48 hours before the procedure and should restart it once kidney function is confirmed to be normal. Patients with very poor nutritional status, liver dysfunction, severe pulmonary disease, or those who consume excessive alcohol should also be cautious about taking this medication. During pregnancy, this medication should be avoided if there is a risk of placental insufficiency, pre-eclampsia, or intrauterine growth restriction. There is a risk of lactic acidosis and hypoglycemia when meals are irregular, intense exercise is performed, or interacting medications are taken, so caution should be exercised. Lactic acidosis is rare but can be a very serious side effect; symptoms such as fatigue, muscle pain, difficulty breathing, and abdominal pain should be reported to healthcare professionals immediately. This medication may commonly cause gastrointestinal disorders, diarrhea, nausea, and vomiting during initial treatment, which can be alleviated by taking it with meals or by gradually increasing the dose. Skin rashes, blood abnormalities, liver function abnormalities, and rarely hypoglycemia can occur, so if there are any abnormal symptoms, one should consult a physician immediately. Renal function should be monitored regularly, especially in elderly patients or those with reduced kidney function, who require more caution. This medication has an increased risk of lactic acidosis when taken with alcohol, so alcohol consumption should be avoided. Additionally, this medication can affect blood sugar control when taken with other hypoglycemic agents, so it should be taken according to medical advice. During pregnancy, consider the effects on the fetus; use only if necessary, and during breastfeeding, this medication is excreted in breast milk, so the decision to breastfeed should be made carefully. In cases of overdose, blood dialysis may be required, so the dosage must be strictly adhered to. This medication should be kept out of reach of children and not transferred to other containers.

Serious side effects

Lactic acidosis (fatigue, muscle pain, difficulty breathing, weakness, abdominal pain, low body temperature, hypotension, resistant bradycardia arrhythmia), severe allergic reactions (hives, severe swelling), serious skin reactions (severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, cough with fever and respiratory irregularities), liver abnormalities (yellowing of the skin or eyes)

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, delayed hypoglycemia

This medication should be stored in a tightly sealed container that is well-ventilated, at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the effectiveness of the medication for a longer period.

Appearance

White round film-coated tablet

Package unit

500 tablets/bottle