S-one MP Tablet 40 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be swallowed with liquids such as water and should not be chewed or crushed. 1. Adults 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. In patients whose esophagitis is not treated or whose symptoms persist, an additional 4 weeks of treatment is recommended. - Long-term maintenance therapy to prevent recurrence in esophagitis patients: 20 mg once daily.

Children's dosage

Adolescents aged 12 and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. Increasing the duration by another 4 weeks if esophagitis is not treated or symptoms persist.

This medication should not be administered to certain patients. For example, patients with an allergy to this medication, any of its ingredients, or benzimidazole class drugs, or with a history of hypersensitivity should not take this medication. Furthermore, patients allergic to penicillin antibiotics or macrolide antibiotics used in the eradication treatment for Helicobacter pylori should also refrain from using this medication. Serious interactions may occur when this medication is taken with certain specific drugs; therefore, patients taking terfenadine, cisapride, pimodidine, or astemizole should not use this medication concurrently. Additionally, patients taking antiviral drugs such as atazanavir or nelfinavir should avoid this medication. The safety of this medication during breastfeeding has not been established, so nursing mothers should avoid its use. Patients with a history of myocardial infarction or currently experiencing myocardial infarction should also not be treated with this medication. Various adverse reactions may occur while taking this medication, with common symptoms including headache, abdominal pain, diarrhea, constipation, nausea, and vomiting. Rarely, serious side effects such as reduction in blood cell counts, hypersensitivity reactions, hypomagnesemia, mental confusion, skin rash, and abnormal liver function have been reported. Notably, if symptoms of muscle pain or weakness occur, there is a possibility of severe muscle damage called rhabdomyolysis, so immediate consultation with a doctor is necessary. This medication can increase bacterial proliferation in the stomach by suppressing gastric acid secretion, which may increase the risk of diarrhea caused by Clostridium difficile in hospitalized patients. Patients taking this medication for a long period (especially over one year) should have regular blood tests and magnesium level checks, and caution is required for those with osteoporosis as the risk of fractures may increase. During treatment with this medication, there are many interactions with other drugs, so especially when taken together with warfarin, digoxin, methotrexate, or clopidogrel, consultation with a physician or pharmacist and monitoring are necessary. The safety of this medication during pregnancy has not been fully established, so it should be used cautiously in pregnant women, and it is safe not to take it if breastfeeding. In cases of overdose, there is no specific antidote; symptomatic treatment based on symptoms may be necessary, and it should be kept out of the reach of children. Additionally, for quality maintenance, it is recommended to avoid transferring it to another container.

Serious side effects

Urticaria, angioedema, anaphylaxis reactions/shock, fever, hyponatremia, hypomagnesemia, mental confusion, hepatitis, jaundice, liver failure, encephalopathy, skin and mucous membrane syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), muscle weakness, interstitial nephritis, severe edema, Clostridium difficile-associated diarrhea,

Mild side effects

Headache, dizziness, sensory disturbances, drowsiness, taste disorders, blurred vision, bronchospasm, abdominal pain, constipation, diarrhea, abdominal bloating, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, increased liver enzymes, dermatitis, itching, rash, hair loss, photosensitivity, fractures, arthralgia, myalgia, gynecomastia, weakness, increased sweating, Clostridium difficile-associated diarrhea, allergic reactions, chest pain, facial swelling, flushing, fatigue, fever,

This medication may be sensitive to air and moisture, so it should be stored in a sealed container. The recommended storage temperature is between 1 degree and 30 degrees Celsius at room temperature. This helps maintain the medication's effectiveness for a long time.

Appearance

Pink, round film-coated tablet

Package unit

For domestic use: 28 tablets (14 tablets/PTP x 2) For export: 28 tablets (14 tablets/PTP x 2), 30 tablets/bottle