Raniska Tablet 150 mg (Ranitidine Hydrochloride)

Adult dose

For adults, the dosage is 150 mg orally twice a day, once in the morning and once at bedtime as ranitidine. For gastric and duodenal ulcers, 150 mg may be taken twice a day or 300 mg once daily at bedtime. For duodenal ulcer patients, 300 mg may be given twice daily, both in the morning and at bedtime. For patients with recurrent ulcers, maintenance treatment with 150 mg is recommended.

Child dose

For children aged 8 to 18 years, a single dose of 150 mg (2 mg per kg of body weight) may be administered up to twice a day.

This medication should not be used by patients who have had an allergic reaction to this medication or its components. It should also not be administered to patients with a rare condition called acute porphyria as it may induce seizures. Patients with impaired kidney function may not eliminate this medication efficiently, leading to elevated blood concentrations, and may require dosage reduction or increasing dosing intervals. Patients with liver dysfunction should use this medication with caution, and those with a history of drug allergies should be given it carefully. Regular monitoring is needed for elderly patients or those taking NSAIDs to reduce the risk of side effects. This medication may mask symptoms of gastric cancer, so patients recently showing dyspeptic symptoms, especially those with gastric ulcers or over middle age, should confirm malignancy before using this drug. Patients with Helicobacter pylori infections in gastric or duodenal ulcers should undergo treatment to eliminate the bacteria. Rarely, serious allergic reactions such as anaphylactic shock may occur, requiring immediate discontinuation and medical treatment if abnormal symptoms arise. If symptoms like urticaria, rash, difficulty in breathing, or low blood pressure occur, discontinue the medication and consult a physician immediately. Decreased blood cell counts, impaired liver function, abnormal heart rhythms, digestive symptoms, and neurological symptoms may occur infrequently, necessitating immediate consultation with healthcare providers if symptoms appear. Special care is needed to monitor for confusion or seizures in patients with kidney impairment. Regular blood tests, liver function tests, and kidney function tests should be performed to confirm treatment efficacy and detect any side effects. Elderly patients and those with chronic lung disease or diabetes, as well as those with weakened immune systems, may face a heightened risk of pneumonia while taking this medication. Driving or operating dangerous machinery should be avoided if dizziness or drowsiness occurs during treatment. Co-administration of other medications may affect absorption or metabolism, particularly regarding anticoagulants like warfarin, necessitating close monitoring of coagulation status. Co-administration with high doses of sucralfate may reduce the absorption of this medication, so it is advisable to space the doses two hours apart. Pregnant women or those who may become pregnant should only use this medication when the benefits outweigh the risks as its safety has not been established. Nursing mothers should also be wary since the drug is excreted in breast milk and use should be carefully considered only when necessary. The safety in children has not been sufficiently verified, hence caution is needed. Elderly patients may require adjustments in dosage and timing due to decreased kidney function leading to increased medication concentration. No serious issues have been reported with overdose, though emergency measures such as vomiting or gastric lavage may be necessary, and hemodialysis may be utilized to remove the drug if needed. This medication should be kept out of reach of children and transferring it to other containers may cause deterioration in quality or accidents.

Serious side effects

Anaphylactic shock, angioedema, bronchospasm, severe allergic reactions, severe skin adverse reactions, respiratory problems, jaundice, hepatitis, severe swelling or abnormalities in urination, aplastic anemia, myelodysplastic syndromes, aplastic anemia, agranulocytosis, autoimmune hemolytic anemia, acute pancreatitis, seizures, altered consciousness, muscular spasms, rhabdomyolysis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and aplastic anemia.

Mild side effects

Urticaria, rash, fever, angioedema, low blood pressure, chest pain, granulocytopenia, elevated serum creatinine levels, leukopenia, thrombocytopenia, temporary and reversible liver function impairment, bradycardia, heart block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal bloating, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, headache, a feeling of heaviness, insomnia, agitation, anxiety, confusion, depression, hallucinations, blurred vision, involuntary movements, and menstrual irregularities.

This medication should be stored in a tightly sealed container that is protected from light as it may degrade if exposed. It is also recommended to keep the medicine at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication safely.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle