Code Desmopressin 0.1 mg (Desmopressin Acetate)

Adult dose

Treatment of nocturia associated with nocturnal polyuria (adults only) : Administer 0.1mg of desmopressin acetate orally at bedtime. If the effect is insufficient after one week, increase the dose to 0.2mg; if the effect remains insufficient, the dose may be increased at one-week intervals up to 0.4mg. Discontinue treatment if there is no clinical benefit within 4 weeks after dose determination.

Child dose

Primary nocturnal enuresis (5 years of age and older) : Administer 0.2mg of desmopressin acetate orally at bedtime. If the effect is insufficient, the dose may be increased to 0.4mg. Whether to continue treatment should be determined 3 months after starting treatment, after withholding treatment for at least 1 week.

This medication may cause hyponatremia and water intoxication in elderly patients or those with certain diseases, so it is important to hydrate appropriately to the level of feeling thirsty. Patients with hypersensitivity to this medication or with certain conditions such as heart failure, kidney failure, or syndrome of inappropriate antidiuretic hormone secretion should not use it. Caution is advised when using this medication in patients with hypertension, chronic kidney disease, pregnant women, children, and the elderly, and particularly in patients with fluid and electrolyte imbalances. Serious side effects such as coma, seizures, and weight gain may occur during the use of this medication, so if any unusual symptoms occur, it is important to consult a healthcare professional immediately. Fluid intake should be limited from 1 hour before administration to 8 hours after administration, and during kidney function tests, it should be limited to a maximum of 0.5 liters for up to 12 hours. Elderly patients are at higher risk of hyponatremia; therefore, serum sodium levels should be frequently monitored before and during treatment. Patients with nocturia should record the frequency and volume of urination before dosing for accurate diagnosis. Treatment should be discontinued if there are fluid and electrolyte imbalances due to acute infections, fever, or gastroenteritis. This medication may interact with other drugs; therefore, close monitoring by healthcare professionals is needed when used with drugs that may increase antidiuretic effects or elevate the risk of hyponatremia. Women who are pregnant or may become pregnant should use this medication cautiously, and nursing mothers are advised to discontinue breastfeeding.

• coma
• convulsions
• weight gain
• severe water intoxication
• hyponatremia
• allergic reactions
• emotional disturbances
• headache
• abdominal pain
• nausea

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 to 30 degrees Celsius to preserve the drug's effectiveness.

Appearance

White or light yellow powder

Package unit

30 packets (450 mg/packet × 30)/case