Fronclor Dry Syrup 125 mg/5 mL (Cefaclor Hydrate)

Adult dosage

As Cefaclor, administer 250 mg (potency) every 8 hours orally. For severe infections (such as pneumonia) and infections with reduced susceptibility, the dose may be doubled. In cases of acute gonococcal urethritis, administer 3 g of this drug along with 1 g of probenecid as a single dose.

Children's dosage

Administer 20 mg (potency) per kg of body weight divided every 8 hours. In cases of severe infections, otitis media, or infections with reduced susceptibility, it may be increased to 40 mg (potency) per kg of body weight per day, with a maximum dose of

This drug works by binding to certain proteins and disrupting bacterial cell wall synthesis, leading to bacterial death. This drug should not be used in patients who have previously experienced severe allergic reactions or shock due to this medication. Patients who are allergic to this drug or to cephalosporin class antibiotics should also avoid its use. This drug contains lactose, thus individuals with galactose intolerance, lactase deficiency, or glucose-galactose malabsorption should not take it. Patients allergic to penicillin antibiotics or with allergic predisposition, severe renal diseases, those who have difficulty swallowing medications, elderly patients, and those with a history of gastrointestinal disease should use this drug cautiously. This drug may rarely cause severe allergic reactions, skin rashes, blood abnormalities, liver or kidney dysfunction, gastrointestinal issues, respiratory symptoms, central nervous system abnormalities, and others; thus, any abnormal symptoms during treatment should be discussed immediately with healthcare personnel. To prevent the emergence of resistant bacteria, the susceptibility of the infectious bacteria should be confirmed, and it should only be used for the necessary minimum duration. Caution is needed as this drug can interact with other medications, especially those affecting the kidneys, anticoagulants, and oral contraceptives. Women who are pregnant or may become pregnant should carefully consider the risks and benefits of using this drug; those who are breastfeeding should also exercise caution. Safety and efficacy in newborns less than 1 month old have not been established, so its use should be avoided. Elderly patients have decreased bodily functions, thus the risk of side effects is higher; therefore, dosage and administration intervals should be adjusted and observed cautiously. Some urine tests may show false positive results when using this medication, so care should be taken in interpreting test results.

Serious side effects

• Shock
• urticaria
• edema
• dyspnea
• angioedema
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• agranulocytosis
• pancytopenia
• aplastic anemia

Mild side effects

• Generalized flushing
• sensory disturbances
• syncope
• hypertension
• vasodilation
• rash
• itching
• fever
• lymphadenopathy
• arthralgia

This medication is sensitive to light; therefore, it should be stored in a container that does not allow light exposure, at room temperature between 1 to 30 degrees Celsius. It is important to avoid direct sunlight and maintain appropriate temperature until the medication is used.

Appearance

Pink dry syrup to be dissolved when used

Package unit

150 mL/bottle