Pred Tablet 4 mg (Methylprednisolone)

Adult use

1. The initial dose may range from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, although a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is obtained. If satisfactory clinical results are not achieved after a reasonable period, discontinue treatment and switch to another appropriate therapy. The dose must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, an appropriate maintenance dose should be determined by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. Continued monitoring of the dose is required. Situations that may require dose adjustment include improvement or worsening of the disease, individual patient response to the medicine, and the effect on the patient of exposure to stressful circumstances unrelated to the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dose for a period sufficient to achieve satisfactory control of the patient's condition. After long-term treatment, gradual dose reduction is recommended when discontinuing the medicine. 2. Multiple sclerosis For treatment of acute exacerbations of multiple sclerosis, administration of prednisolone 200mg daily for 1 week followed by prednisolone 80mg every other day for 1 month is effective (4mg of methylprednisolone is equivalent to 5mg of prednisolone). 3. ADT (Alternate Day Therapy) Alternate-day therapy is a regimen in which twice the daily dose is administered on one morning every other day. Although a single morning dose produces considerably less adrenal suppression than taking prednisolone (10mg) in 4 divided doses every 6 hours, evidence indicates that when pharmacologic doses are used, some suppression of adrenal activity continues into the following day. The initial suppressive dose should be continued until a satisfactory clinical response is achieved, usually for 4 to 10 days for many allergic and collagen diseases. ① Switch to ADT and gradually reduce the amount of corticosteroid given every other day. ② Depending on control of disease progression, reduce the daily corticosteroid dose to the minimum effective level as soon as possible, then change to an alternate-day schedule. If this proves difficult, it may be preferable to administer 3 times, or even 4 times, the daily dose every other day rather than simply doubling the daily dose. Once the patient is controlled again, attempt to reduce this dose to the minimum. If an acute exacerbation occurs during disease progression, it may be necessary to return to a fully suppressive corticosteroid dose divided throughout the day for control. Once control is achieved, the established alternate-day regimen may be retried.

This medication should not be used in patients with certain allergic reactions or infections. Also, it should not be administered to patients receiving live vaccines or those with lactose intolerance. Patients with conditions such as glaucoma, tuberculosis, peptic ulcers, hypertension, and diabetes should use this medication cautiously, as symptoms may worsen. During the course of taking this medicine, symptoms like edema, muscle weakness, digestive disturbances, skin changes, and mental abnormalities may occur, so these symptoms should be closely monitored. Long-term use may lead to adrenal suppression, and abrupt discontinuation can result in serious side effects; therefore, the dose should be gradually reduced. Since immune function is suppressed, there is an increased risk of infections, and care should be taken to prevent infections, especially avoiding exposure to varicella or measles. This medication may interact with various drugs, so if any other medications are being taken, it is essential to inform the healthcare provider. Pregnant or breastfeeding women should consult a physician before use, as it may affect the fetus or newborn. In children, there may be side effects such as growth retardation, so it should be cautiously administered at the minimal effective dose, and elderly patients face a higher risk of side effects, so caution is warranted.

edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral head, steroid myopathy, muscle wasting, pathologic fractures of the pelvis, osteoporosis, vertebral compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, dry mouth, vomiting, gastric pain, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, ulcerative esophagitis, diarrhea, delayed wound healing, facial erythema, thin and delicate skin, abnormal sweating, petechiae, purpura, suppression of skin reactions, purpura, acne, hirsutism, alopecia, pigmentation, papilledema, increased intracranial pressure, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, symptoms of latent diabetes mellitus, secondary adrenal insufficiency, pituitary non-responsiveness, decreased glucose tolerance, increased requirements for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior capsule cataract, secondary eye infections due to fungi or viruses, retinal disorders, proptosis, negative nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It should be kept at room temperature, between 1 to 30 degrees Celsius, to maintain its efficacy.

Appearance

White oval tablets

Package unit

30 tablets/bottle, 500 tablets/bottle