Amocle 375 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

Adults and children 12 years or older or weighing 40 kg or more should take amoxicillin/clavulanate potassium as a single dose of 250 mg/125 mg, administered orally three times a day every 8 hours. In case of severe and respiratory infections, the dose may be increased to 500 mg/125 mg per dose. In cases of renal impairment, the dosage should be adjusted according to creatinine clearance. For a creatinine clearance of 10-30 mL/min, use 250 mg/125 mg every 12 hours.

Child dose

Children under 12 years or those weighing less than 40 kg should be dosed in a reduced manner using the same method.

This drug, being a penicillin class antibiotic, should not be used in certain patients. For example, it should not be administered to patients with allergies or hypersensitivity reactions to its components or beta-lactam drugs. Additionally, caution is needed for patients with viral infections such as infectious mononucleosis or lymphocytic leukemia, as they are at a higher risk for rash. Patients with a history of liver dysfunction or jaundice should also avoid using this drug, as symptoms may recur. Patients with impaired liver function or moderate to severe kidney function impairment may experience increased drug concentrations, so dosing intervals should be adjusted or used with caution. Patients with allergic constitutions, those unable to take the drug orally, and the elderly may be at risk for bleeding due to vitamin K deficiency, so caution is advised. This drug can cause various gastrointestinal side effects, and serious intestinal conditions such as diarrhea or pseudomembranous colitis may occur, so usage should be discontinued immediately if symptoms appear. Abnormal liver function tests or hepatitis and cholestatic jaundice may occur, with the elderly and males particularly advised to use it cautiously and avoid long-term use. Skin itching or rashes, in severe cases severe reactions like Stevens-Johnson syndrome may occur, so drug use should be stopped immediately if such symptoms arise. Blood-related abnormalities such as leukopenia, thrombocytopenia, and anemia may rarely occur, so symptom observation is necessary. Central nervous system symptoms such as dizziness, convulsions, and confusion may also rare occur, and patients with impaired kidney function are at risk for acute renal failure. This drug may interact with other medications, so particularly patients taking anticoagulants, anti-inflammatory drugs, or oral contraceptives should consult a doctor. Pregnant or breastfeeding women may find the use of this drug to be risky, and should always consult a physician before use, especially during the first three months of pregnancy. It is not recommended for children under 12 years or those weighing less than 40 kg. The elderly may experience side effects more easily due to decreased physiological function, so dosages and intervals should be adjusted and used carefully. In case of overdose, symptoms such as vomiting, diarrhea, and abdominal pain may occur, and in severe cases renal failure or convulsions may occur, so immediate medical attention is required. This drug should be stored in a dry place below 25 degrees Celsius and if any adverse reactions occur during usage, immediate consultation with a professional is necessary.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, high fever with severe rashes, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory difficulties accompanied by cough + fever, respiratory problems, jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden onset

Mild side effects

• Diarrhea
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain
• abdominal distension

This drug should be kept in a tightly sealed container to prevent moisture from entering, and it is important to maintain a cool temperature between 1 and 25 degrees during storage. Proper storage will help maintain the drug's effectiveness and prevent degradation.

Appearance

White or nearly white oval film-coated tablets

Package unit

100 tablets/box [(10 tablets/PTP x 10)], 80 tablets/box [(8 tablets/PTP x 10)]