Medication info
Latogagen 10 mg (Rabeprazole)

Latogagen 10 mg (Rabeprazole)

Prescription medicationTabletOral
Ingredient · strength
Lafutidine›10mg / 1 tablet
Manufacturer / importer
Hanol BioPharma Co., Ltd.
Appearance
White round film-coated tablets
Packaging
30 tablets/bottle, 300 tablets/bottle
Approval status
Active

MFDS item code 201401316 · Approved 2014.03.21 · Insurance code 655604600

Summary

Main use
Treatment of gastrointestinal disorders (such as ulcers and gastritis), combination therapy for eradication, and preanesthetic medication
Who takes it
Adults
Adult dose
1. Short-term treatment of gastric ulcers: The usual dose of lafutidine is 10mg orally twice daily, in the morning and before bedtime. Clinical trials with treatment for up to 8 weeks showed that most ulcers healed within 8 weeks, although healing time may occasionally vary between patients. 2. Short-term treatment of duodenal ulcers: The usual dose of lafutidine is 10mg orally twice daily, in the morning and before bedtime. Clinical trials with treatment for up to 6 weeks showed that most ulcers healed within 6 weeks, although healing time may occasionally vary between patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis: The usual dose of lafutidine is 10mg orally once daily before bedtime. Clinical trials with treatment for up to 2 weeks showed that most lesions healed within 2 weeks, although healing time may occasionally vary between patients. 4. Antibiotic combination therapy for patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication: The usual dose of lafutidine is 10mg per dose, administered orally twice (before bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer lafutidine 10mg per dose orally twice daily.

Ingredients

Manufacturer
Hanol BioPharma Co., Ltd.

Efficacy & effects

Treatment of gastrointestinal disorders (such as ulcers and gastritis), combination therapy for eradication, and preanesthetic medication

  • Gastric ulcers
  • duodenal ulcers
  • acute gastritis
  • chronic gastritis mucosal lesions
  • peptic ulcers
  • gastroesophageal reflux disease
View approved original text

Used to treat gastric ulcers and duodenal ulcers, improving gastric mucosal damage caused by acute and chronic gastritis. For patients with peptic ulcers infected with Helicobacter pylori, it is administered in combination with antibiotics to enhance therapeutic effects. Additionally, it is used pre-anesthesia and can aid in the treatment of gastroesophageal reflux disease. This medication is effective in alleviating symptoms related to gastrointestinal disorders and promoting healing.

How to take

Adult dose

1. Short-term treatment of gastric ulcers: The usual dose of lafutidine is 10mg orally twice daily, in the morning and before bedtime. Clinical trials with treatment for up to 8 weeks showed that most ulcers healed within 8 weeks, although healing time may occasionally vary between patients. 2. Short-term treatment of duodenal ulcers: The usual dose of lafutidine is 10mg orally twice daily, in the morning and before bedtime. Clinical trials with treatment for up to 6 weeks showed that most ulcers healed within 6 weeks, although healing time may occasionally vary between patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis: The usual dose of lafutidine is 10mg orally once daily before bedtime. Clinical trials with treatment for up to 2 weeks showed that most lesions healed within 2 weeks, although healing time may occasionally vary between patients. 4. Antibiotic combination therapy for patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication: The usual dose of lafutidine is 10mg per dose, administered orally twice (before bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer lafutidine 10mg per dose orally twice daily.

Precautions

This medication should not be used by patients who are allergic to any of the components. It contains lactose; therefore, patients with genetic issues such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not use it either. Administer with caution in patients with a history of allergic reactions to the drug, decreased liver or kidney function, those undergoing dialysis, and the elderly. This drug can cause severe allergic reactions such as anaphylaxis; if there are symptoms like facial pallor, low blood pressure, reddening of the skin, or difficulty breathing during administration, immediately discontinue and receive appropriate treatment. Liver function may be affected, and frequent liver function tests should be conducted, with discontinuation if abnormalities are found. A decrease in blood cell counts such as agranulocytosis or thrombocytopenia can occur. If symptoms like pharyngitis, lethargy, or fever arise, stop administration and consult a doctor. Severe side effects such as skin rashes, seizures, and heart rhythm abnormalities can rarely occur, so report unusual symptoms to a healthcare professional immediately. Gastrointestinal symptoms can include constipation, diarrhea, nausea, vomiting, abdominal bloating, and loss of appetite. Central nervous system symptoms reported include headaches, insomnia, drowsiness, confusion, hallucinations, consciousness disturbance, and dizziness. Regular blood tests may reveal changes in white blood cell counts, elevated liver enzyme levels, and kidney function abnormalities. This drug is used for treating gastric ulcers and gastroesophageal reflux disease; during treatment, malignant tumor symptoms may be masked. If symptoms such as weight loss, vomiting, or bleeding occur, be sure to undergo examinations. The elderly should be observed closely for ability to function due to decreased physical capabilities; dosing and intervals should be adjusted with care. For dialysis patients, drug concentrations in blood may increase, necessitating careful administration starting from lower doses. Pregnant women should only use it if the benefits outweigh the risks as deemed by a doctor; nursing women are advised against it as the drug may be excreted in breast milk. Safety in children has not been sufficiently established, thus caution is necessary in their use. This medication should be stored out of reach of children and in its original container to prevent misuse or degradation in quality. Lastly, although animal tests showed no carcinogenicity, hyperplasia of endocrine neurocytes and some toxic symptoms were observed at high doses, so it is important to adhere to recommended doses.

Side effects

  • Shock
  • anaphylaxis symptoms
  • pallor
  • hypotension
  • generalized rash
  • dyspnea
  • liver dysfunction
  • jaundice
  • agranulocytosis
  • pharyngitis
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  • general fatigue
  • fever
  • thrombocytopenia
  • pancytopenia
  • aplastic anemia
  • seizures
  • interstitial nephritis
  • Stevens-Johnson syndrome
  • Lyell's syndrome
  • rhabdomyolysis
  • heart block
  • systolic dysfunction
  • constipation
  • diarrhea
  • hard stools
  • nausea
  • vomiting
  • abdominal distension
  • anorexia
  • headache
  • insomnia
  • drowsiness
  • reversible confusional state
  • hallucinations
  • altered consciousness
  • dizziness
  • chills
  • sense of heat
  • facial flushing
  • leukocytosis
  • eosinophilia
  • leukopenia
  • erythrocytopenia
  • decreased hematocrit
  • elevated ALT
  • elevated AST
  • elevated Al-P
  • elevated γ-GTP
  • elevated T-Bil
  • elevated LDH
  • elevated TTT
  • abnormal urinary protein
  • elevated BUN
  • elevated serum uric acid
  • elevated Cl
  • delayed maturation
  • elevated Na
  • decreased K
  • gynecomastia
  • edema
  • fatigue
  • glossitis
  • headache
  • urticaria
  • skin rash
  • abdominal pain
  • dyspepsia
  • enteritis
  • gastric ulcer
  • erosive gastritis
  • duodenitis
  • distension
  • rinopharyngitis
  • upper respiratory infection
  • bronchopneumonia
  • tinea
  • carotid artery stenosis
  • cough
  • oropharyngeal pain
  • oropharyngeal discomfort
  • productive cough
  • fatigue
  • chest pain
  • limb pain
  • arthralgia
  • neck pain
  • pruritus
  • acne
  • contusion
  • insomnia
  • non-alcoholic fatty liver disease

Not everyone experiences these, and they can vary from person to person.

Storage

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. It is best to maintain storage temperatures between 1 and 30 degrees Celsius at room temperature. This will help preserve the drug's effectiveness for a longer time.

Appearance and packaging

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.