Ciclin Tablet (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) per dose, 2 times daily. For severe infections, administer 500mg (potency) per dose, 2 times daily. The usual treatment duration is 7～14 days. In patients with renal failure with a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose, 2 times daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose, 2 times daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose, 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years or older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. Patients who are allergic to any component of this drug or have had hypersensitivity reactions to similar classes of antibiotics should not take it. Additionally, patients with certain heart diseases or severely impaired liver and kidney function should not take this medication. Pregnant or breastfeeding women should also avoid this drug, and patients with central nervous system infections are excluded from treatment. Patients taking other medications that may pose risks when used together with this drug should exercise caution. Patients with slight impairment of kidney or liver function, patients with heart disease, elderly patients, and those taking other antibiotics should use this drug carefully. Patients with a history of allergies should also be administered this medication with caution, based on the physician's judgment. This drug can rarely cause serious allergic reactions, skin rashes, gastrointestinal disturbances, liver dysfunction, kidney problems, central nervous system abnormalities, hearing issues, and other side effects. Therefore, if any unusual symptoms occur while taking the medication, immediate consultation with a doctor is necessary. This medication should only be taken for the necessary duration to prevent antibiotic resistance; prolonged use may lead to the emergence of resistant bacteria or dysbiosis, thus caution is required. There are many drug interactions, and co-administration may change drug concentrations or increase the risk of side effects, so it is essential to inform your doctor or pharmacist of any medications you are currently taking. It is safest not to take this medication during pregnancy or breastfeeding; if it is absolutely necessary, consult healthcare professionals. Caution should be exercised with dosing in children and elderly patients, especially those with impaired kidney function, as dosage adjustments may be necessary. In case of overdose, gastrointestinal disturbances or central nervous system abnormalities may occur, so precautions against overdose should be taken, and if unusual symptoms arise, seek medical attention immediately. This drug should be stored in a tightly closed container to prevent it from being affected by air or moisture. It is best to be stored at room temperature between 1 and 30 degrees Celsius.

Shock, anaphylactic symptoms, respiratory distress, convulsions, flushing, rash, itching, urticaria, erythema, angioedema, joint swelling, drug eruption, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stool, membrane-associated colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug eruption accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, hepatic dysfunction, hepatic failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, loss of appetite, dark urine, itching, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased myoglobin in blood, increased myoglobin in urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste dysfunction, hearing loss, dysesthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory dysfunction, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis, muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea, nephritis, venous thrombophlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased alkaline phosphatase in blood, increased lactate dehydrogenase in blood, increased international normalized ratio, prolonged prothrombin time, urine discoloration, soft tissue infection, candidiasis, gastritis, infection, vaginal infection, herpes simplex virus, superficial soft tissue infection, erythema nodosum, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, hypersensitivity anaphylactic reaction, angioedema, decreased appetite, insomnia, neuralgia, loud noises, psychotic disorder, state of confusion, abnormal dreams, movement disorders, non-vestibular dizziness, drowsiness, tremor, vestibular dizziness, hearing loss, cardiac arrest, atrial fibrillation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, cholestasis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura

This medication should be stored in a tightly closed container to prevent it from being affected by air or moisture. It is advisable to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle