Dithyurin Tablets 0.2 mg (Desmopressin Acetate)

Adult dose

Treatment of nocturia associated with nocturnal polyuria (adults only) : Administer desmopressin acetate 0.1mg orally at bedtime. If the effect is insufficient after one week, increase the dose to 0.2mg. If the effect remains insufficient, the dose may be increased at one-week intervals up to 0.4mg. Discontinue treatment if there is no clinical effect within 4 weeks after dose titration. Initiating treatment with this medicine is not recommended in patients aged 65 years and older. In elderly patients who require treatment, monitor serum sodium levels closely. (See section 5, General Precautions, under Precautions for Use.)

Child dose

Primary nocturnal enuresis (5 years and older): Administer desmopressin acetate 0.2mg orally at bedtime. If the effect is insufficient, the dose may be increased to 0.4mg. Whether to continue treatment should be determined after 3 months of administration, following a treatment-free period of at least 1 week.

This medication helps regulate body water levels. However, elderly patients or those with certain medical conditions are at higher risk for hyponatremia and water intoxication when taking this medication, which could lead to a state of coma; therefore, adequate fluid intake just enough to relieve thirst is necessary. Patients with hypersensitivity to this medication or specific diseases such as severe renal failure, heart failure, and nephrogenic diabetes insipidus should not take this medication. In particular, this medication should only be used in patients with normal blood pressure for the treatment of enuresis, and those with genetic lactose intolerance should also avoid taking it. Caution is especially needed when using this medication in individuals with hypertension, chronic kidney disease, pregnant women, children, and the elderly, as there is an increased risk of fluid and electrolyte imbalance. Fluid intake should be restricted during the use of this medication, and excessive fluid intake should be avoided, especially for a period of time before and after administration. Otherwise, side effects such as headache, nausea, weight gain, and cramps may occur. Additionally, this medication can interact with other drugs, so it is important to consult with healthcare professionals when used in conjunction with antidepressants, diuretics, steroids, etc., and to monitor the condition through blood tests. Pregnant or breastfeeding women need to be cautious while taking this medication, as it may affect the fetus or newborn, and it is recommended to stop breastfeeding if using it during lactation. In case of overdose, symptoms such as headache, nausea, cramps, and loss of consciousness may occur, so it is important to inform healthcare providers immediately, and appropriate measures such as fluid restriction and diuretics if necessary are required. Finally, this medication does not affect the ability to drive or operate machinery, but caution is needed in case of side effects occurring.

• coma
• seizures
• weight gain
• hyponatremia
• water intoxication
• allergic reaction
• emotional disturbances
• headache
• abdominal pain
• nausea

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1°C and 30°C. Doing so helps to maintain the drug's efficacy and safety for a prolonged period.

Appearance

White, convex, round tablet

Package unit

30 tablets/bottle