Diamin Tablet 500mg (Metformin Hydrochloride)

Adult dose

The dosing for adults should be determined based on the individual drug effect and tolerance, and should not exceed the recommended maximum daily dose. This medication should be initiated at a low dose to reduce gastrointestinal adverse reactions and establish the minimum effective dose required for adequate blood sugar control, and should be taken three times a day with meals at a dose of 500 mg each. The dose may be gradually increased by 500 mg each week, and if the total daily dose reaches 2000 mg, it is typically divided into two doses for morning and evening. If the dose exceeds 2000 mg, it should be taken three times a day with meals, with a maximum daily dose of 2550 mg. To measure the treatment response to this medication and determine the minimum effective dose during dose initiation and adjustments, fasting blood sugar should be measured. The glycated hemoglobin levels should be measured approximately every 3 months. The treatment goal with this medication, whether used alone or in combination with sulfonylureas or insulin, is to reduce fasting blood sugar and glycated hemoglobin levels to normal or near-normal levels with the least effective dose. Generally, this medication can provide adequate effects for patients whose blood sugar was previously controlled with dietary therapy alone but have temporarily lost control. Children and adolescents This medication can be used for children over 10 years or adolescents. The general starting dose is 500 mg taken once daily during or after meals. Blood sugar levels should be measured one week later to adjust the dose. Gastrointestinal adverse effects may improve with gradual dose escalation. The maximum daily dose is 2000 mg and should be divided into 2-3 doses.

Child dose

For children over 10 years or adolescents, the general starting dose is 500 mg once daily taken during or after meals. Blood sugar levels should be monitored one week later to adjust the dose.

This medication may cause severe lactic acidosis or hypoglycemia, so caution is necessary. It should not be administered to patients with moderately impaired renal function, those who are dehydrated, or those with severe infections or rapidly declining heart function. Patients undergoing tests using radiographic iodine contrast agents should temporarily suspend this medication before and after the examination, and can only resume it after renal function has returned to normal. Patients with hypersensitivity to this medication or with a history of type 1 diabetes or diabetic ketoacidosis should not use it. In cases of severe infections, serious injuries, or before and after surgery, the use of this medication should be temporarily suspended, and it should be resumed only after the patient’s condition has stabilized. Patients with liver dysfunction, excessive alcohol consumption, or gastrointestinal disorders should also exercise caution when using this medication. Pregnant women at risk of placental insufficiency or preeclampsia should avoid using this medication. Since this drug is primarily excreted through the kidneys, renal function should be monitored regularly, and the medication should be discontinued if renal function declines. Additionally, due to the risk of hypoglycemia, caution is required during irregular meals, intense exercise, or when used in combination with other hypoglycemics. Lactic acidosis is a rare but serious side effect; if symptoms such as fatigue, muscle pain, difficulty breathing, or abdominal pain occur, immediate medical attention should be sought. Gastrointestinal side effects may include diarrhea, nausea, and vomiting, which can often be alleviated by gradually increasing the dosage or taking the medication with meals. Skin rashes, blood abnormalities, and symptoms of vitamin B12 deficiency may also occur rarely, necessitating regular check-ups. There may be interactions with other medications taken alongside this drug, so it is crucial to inform healthcare professionals about any other medications being used. Blood sugar control is crucial during pregnancy, so careful monitoring of fetal development should be carried out if this medication is used during preconception, throughout pregnancy, and postpartum. If breastfeeding, this medication is excreted in breast milk, so careful consideration must be given to breastfeeding and medication therapy. Elderly patients may experience reduced kidney function; therefore, dosage should be adjusted, and renal function should be monitored regularly. In the case of overdose, drug removal through hemodialysis is possible, so immediate medical assistance should be sought if an overdose is suspected. This medication does not cause weight gain, which may be advantageous for diabetic patients needing weight management. Finally, keep this medication out of the reach of children and do not transfer it to other containers.

Serious side effects

Lactic acidosis (associated with acute kidney function deterioration, cardiopulmonary disease, sepsis), deaths due to severe lactic acidosis, dehydration and impaired kidney function, serum electrolyte imbalances, decreased blood pH, acute myocardial infarction, heart failure, sepsis, hypoxia, severe allergic reactions (including rashes), severe edema, hypotension, resistant bradyarrhythmia, severe neurological symptoms (headache, seizures, altered consciousness, etc.), liver abnormalities (including jaundice), severe

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, dyspepsia, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia, adverse reactions in children are similar to adults.

This medication should be stored in a sealed container to prevent air ingress, and it is advisable to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and prevent degradation.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 500 tablets/bottle