JW 5% Dextrose Injection

Adult administration

Administer 500–1000 mL as an intravenous injection per dose. The intravenous drip rate should be less than 0.5 g/kg per hour as dextrose. Use an appropriate amount for dissolving or diluting the injection. Adjust dosage as necessary based on age and symptoms.

This medication may contain glass fragments when using an ampoule injection, so caution should be exercised when cutting the container. Special care should be taken when administering to children or elderly patients. Patients receiving this medication via intravenous injection should be cautious as there is a risk of vitamin B1 (thiamine) deficiency. This medication should not be used in certain patients, including those with hypertonic dehydration, fluid overload, hyperglycemia, acidosis, hypokalemia, hyperosmolar coma, glucose intolerance, anuria, and hepatic coma. Additionally, it is not used in patients with spinal or intracranial hemorrhage or delirium tremens, as the ingredient in this medication can worsen dehydration symptoms. Patients with tendencies towards potassium, phosphate, and magnesium deficiencies, or conditions such as hyponatremia, diabetes insipidus, renal failure, heart failure, severe malnutrition, thiamine deficiency, sepsis, and severe trauma should receive this medication with caution. Administering this medication in large amounts or rapidly may lead to electrolyte imbalances or fluid overload, pulmonary edema, and other side effects, hence careful monitoring is essential. Excessive administration may result in increased serum bilirubin and lactate levels, as well as hypokalemia, acidosis, dehydration, hyperosmolarity, and polyuria. Intravenous administration can cause fluid overload and electrolyte imbalance, thrombosis, and pain at the injection site. In patients with glucose intolerance, there may be occurrences of hyperglycemia and renal loss, requiring caution. Long-term use may affect insulin production; hence, insulin should be administered concurrently if necessary. After surgery or trauma, or in patients with glucose intolerance, blood sugar levels should be tightly controlled during administration, with regular monitoring of serum electrolytes, fluid balance, and blood glucose concentrations. The safety of this medication during pregnancy has not been established; therefore, it should be administered cautiously considering the risk to the fetus. Administering this medication during labor may pose risks of hyperglycemia and hypoglycemia, as well as metabolic acidosis for both the mother and newborn, requiring caution. Newborns, especially preterm or low birth weight infants, are at higher risk for hypoglycemia or hyperglycemia and should be closely monitored for blood sugar control. Elderly patients may have reduced bodily functions, hence special caution should be taken when using this medication. Excessive dosing could lead to hyperglycemia or diabetes symptoms; thus, appropriate measures such as insulin administration should be taken. Subcutaneous injection is not recommended as it may cause localized irritation and circulatory failure. Any unused solution should be discarded immediately after opening. When administering this medication, care should be taken to prevent infections, particularly in cold weather, and the solution should be warmed to body temperature before use. When using in combination with other medications, be fully aware of the potential interactions and adverse reactions and monitor carefully, administering immediately after mixing. To prevent air embolism during administration, care should be taken to avoid injecting air from the container.

Mild side effects

• Hypokalemia
• acidosis
• dehydration
• hyperosmolarity
• polyuria with detection of dextrose
• fluid or solute overload
• fluid electrolyte imbalance
• congestion
• pulmonary edema
• hyperglycemia

This medication should be stored in a sealed container to prevent air ingress and should be kept at room temperature between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the medication and ensure safe use.

Appearance

A colorless and transparent injection solution contained in a polypropylene bottle

Package unit

110mL