Rima Tablets (RimabotulinumtoxinA-Alpha-Dex)

Adult dose

For improvement of ischemic symptoms such as ulcers, pain, and coldness associated with thromboangiitis obliterans (Buerger's disease), the usual adult dose is 2 tablets orally 3 times daily. For improvement of subjective symptoms (lower-limb pain and numbness) and walking ability associated with acquired lumbar spinal stenosis (in patients with a normal SLR test and bilateral intermittent claudication), the usual adult dose is 1 tablet orally 3 times daily. Adjust the dose as appropriate according to age and symptoms.

This medication should not be used by women who are pregnant or may become pregnant. Additionally, because it contains lactose, it should not be administered to patients with lactose intolerance or certain genetic metabolic disorders. Patients with a bleeding tendency or those taking antiplatelet agents, thrombolytics, or anticoagulants should exercise particular caution when using this medication. While taking this medication, hypersensitivity reactions such as rashes or itching may occur, so immediate discontinuation is necessary if these symptoms develop. Bleeding may rarely occur; hence symptoms should be closely monitored, and use should be halted if any abnormalities are observed. Gastrointestinal side effects such as diarrhea, nausea, abdominal pain, loss of appetite, and heartburn may occur, so attention to symptoms is required. Liver dysfunction may develop, thus regular monitoring of liver enzyme levels is necessary. Certain cardiovascular symptoms such as palpitations or low blood pressure may occur, requiring vigilance. Headache, facial flushing, dizziness, warmth, tremors, edema, and anemia have also been reported as other adverse effects. Patients with lumbar spinal stenosis should closely monitor symptom changes when deciding whether to continue long-term treatment with this medication. In particularly severe cases that require surgery, this medication's effectiveness may not be confirmed, and careful judgment is needed. Safety during pregnancy has not been established, and uterine contractions have been reported in animal experiments, hence it should not be used in pregnant women. Safety in children has not been confirmed, so it is advisable not to use it in pediatric patients. Elderly patients may have diminished bodily functions; therefore, careful dosage adjustments are advised. Finally, in healthy adults, excessive dosing may lead to temporary hypotension, so caution is warranted.

• rash
• itching
• bleeding
• diarrhea
• nausea
• abdominal discomfort
• abdominal pain
• loss of appetite
• heartburn
• vomiting

This medication should be stored in a tightly closed container to prevent exposure to air or moisture, and it is safe to store at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness over time.

Appearance

White round tablets

Package unit

84 tablets (21 tablets/PTP × 4)